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Special Issue "Cell Metabolism and Small Natural Compounds 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 371

Special Issue Editors

ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Department of Sustainability, Trisaia Research Center, 75026 Rotondella, Italy
Interests: mitochondria; protein purification; antioxidant activity; biomolecules extraction; waste valorization
Special Issues, Collections and Topics in MDPI journals
Department of Veterinary Medical Sciences, Alma Mater Studiorum - Università di Bologna, Ozzano Emilia, Italy
Interests: F1FO-ATPase; mitochondria; bioenergetics; permeability transition pore; cellular metabolism
Special Issues, Collections and Topics in MDPI journals
Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
Interests: nutraceuticals; mitochondria; membrane proteins; cell metabolism; cardiovascular disease; metabolic syndrome; omics sciences
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue “Cell Metabolism and Small Natural Compounds”.

Cellular metabolism, and especially its dysregulation, plays a key role in the physiology of the onset of many diseases, such as cancer, diabetes, metabolic syndrome, and cardiovascular as well as neurodegenerative diseases.

Over the years, only through in-depth studies of biochemistry and molecular biology has it been possible to better understand the correlation between cellular mechanisms and various chemical mediators.

In particular, the knowledge of and research on the mechanisms that involve the alteration of energy metabolism, the overproduction of reactive oxygen species (ROS) as well as nitrogen species (RNS), the imbalance between proliferation and cell death, and the interaction between enzymes and substrates represent useful and fundamental tools with which to create new therapeutic approaches that are more effective and ensure better quality of life.

Therefore, the detailed study of potential natural mediators of cellular metabolism, both endogenous and exogenous (extracted from animal and plant sources), becomes an interesting research topic to be enriched with information. The multiplicity of bioactive molecules present in nature, which is associated with a potential therapeutic effect and increased tolerability as well as bioavailability, is an excellent alternative to synthetic drugs.

The increased knowledge of altered metabolic pathways and the ability of natural compounds to modulate them are achievements, in addition to great steps forward for science.

Given the particular historical moment in which we are living, this Special Issue aims to focus more attention of the entire scientific community on the great therapeutic potential of natural compounds, and especially on their safety for health.

In particular, we encourage the submission of original manuscripts and reviews that bring new insights as well as information on the biochemical interaction of known or novel natural compounds with cellular metabolism, in health and disease, in order to design new and innovative therapeutic approaches.

Dr. Anna Spagnoletta
Dr. Salvatore Nesci
Dr. Francesca Oppedisano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell metabolism
  • mitochondria
  • ROS
  • RNS
  • proliferation and cell death
  • metabolic pathways
  • natural compounds
  • bioactive molecules
  • human pathology

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Published Papers (1 paper)

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Protective Role of Ethanol Extract of Cibotium barometz (Cibotium Rhizome) against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
Int. J. Mol. Sci. 2023, 24(19), 14798; https://doi.org/10.3390/ijms241914798 - 30 Sep 2023
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Sarcopenia is a progressive muscle disease characterized by the loss of skeletal muscle mass, strength, function, and physical performance. Since the disease code was assigned, attention has been focused on natural products that can protect against muscle atrophy. Cibotium barometz (Cibotium Rhizome) has [...] Read more.
Sarcopenia is a progressive muscle disease characterized by the loss of skeletal muscle mass, strength, function, and physical performance. Since the disease code was assigned, attention has been focused on natural products that can protect against muscle atrophy. Cibotium barometz (Cibotium Rhizome) has been used as an herbal medicine for the treatment of bone or joint diseases in Asian countries. However, no studies have identified the mechanism of action of Cibotium Rhizome on muscle atrophy related to sarcopenia at the site of myotubes. The aim of this study was to investigate the improvement effect of the ethanol extract of Cibotium Rhizome (ECR) on dexamethasone-induced muscle atrophy in an in vitro cell model, i.e., the C2C12 myotubes. High-performance liquid chromatography was performed to examine the phytochemicals in ECR. Seven peaks in the ECR were identified, corresponding to the following compounds: protocatechuic acid, (+)-catechin hydrate, p-coumaric acid, ellagic acid, chlorogenic acid, caffeic acid, and ferulic acid. In atrophy-like conditions induced by 100 μM dexamethasone for 24 h in C2C12, ECR increased the expression of the myosin heavy chain, p-Akt, the p-mammalian target of rapamycin (mTOR), p-p70S6K, and repressed the expression of regulated in development and DNA damage responses 1 (REDD1), kruppel-like factor 15 (KLF 15), muscle atrophy F-box, and muscle-specific RING finger protein-1 in C2C12. In addition, ECR alleviated dexamethasone-induced muscle atrophy by repressing REDD1 and KLF15 transcription in C2C12 myotubes, indicating the need for further studies to provide a scientific basis for the development of useful therapeutic agents using ECR to alleviate the effects of skeletal muscle atrophy or sarcopenia. Full article
(This article belongs to the Special Issue Cell Metabolism and Small Natural Compounds 2.0)
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