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Molecules
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Bioactive Compounds in Pharmaceutical Research
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Bioactive Compounds in Pharmaceutical Research

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4836

Special Issue Editors

Dr. Rathinasamy Baskaran

E-Mail Website
Guest Editor
Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, Taiwan
Interests: bioactive compounds; antioxidants; apoptosis; cancer; biomedicines; polyphenols
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Wan-Teng Lin

E-Mail Website
Guest Editor
Department of Hospitality Management, College of Agriculture, Tunghai University, Taichung, Taiwan
Interests: bioactive peptides; sports nutrition; mitochondrial biogenesis; nutraceuticals; exercise physiology; alternative medicine

Special Issue Information

Dear Colleagues,

Bioactive compounds derived from natural sources possess numerous biological and pharmacological activities. Bioactive compounds from plants, animals, bacterial, and fungal sources are very important in improving health and curing/preventing diseases. The natural bioactive compounds possess different pharmacological actions (such as antioxidant, anticancer, immunomodulatory, anti-inflammatory, anti-diabetic, anti-microbial, cardioprotective, diuretic, anti-aging, osteogenic, wound healing, etc.) and present a wide range of therapeutic activities and hence they are being used in many pharmaceutical applications. Most of the traditional medicine preparations require the use of bioactive natural compounds extracted from the plant. Apart from plant sources, bioactive compounds from animal sources like polyunsaturated fatty acids, polysaccharides, peptides, and enzymes also have many therapeutic values.

This special issue “Bioactive Compounds in Pharmaceutical Research” contains the research and review articles about different bioactive compounds, their pharmacological activity, and potential molecular mechanism in different disease models (E.g.: Cancer, cardiovascular disease; diabetes; aging, diabetes, and infectious diseases). 

Dr. Rathinasamy Baskaran
Prof. Dr. Wan-Teng Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • peptides
  • phytochemicals
  • functional food
  • nutraceuticals
  • biomedicines

Published Papers (2 papers)

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Research

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12 pages, 2446 KiB  
Article
Planispine A Sensitized Cancer Cells to Cisplatin by Inhibiting the Fanconi Anemia Pathway
by Thangjam Davis Singh, Ningthoujam Indrajit Singh, Khuraijam Mrinalini Devi, Remmei Meiguilungpou, Lhaineichong Khongsai, Lisam Shanjukumar Singh, Naresh Chandra Bal, Ningombam Swapana, Chingakham Brajakishor Singh and Thiyam Ramsing Singh
Molecules 2022, 27(21), 7288; https://doi.org/10.3390/molecules27217288 - 26 Oct 2022
Cited by 3 | Viewed by 1694
Abstract
The use of cisplatin as a chemotherapeutic drug is impeded by the development of drug resistance. Combination therapies of a chemosensitizer for cisplatin have been studied, but with little success, and the search for an effective combination therapy is continuing. Our earlier reports [...] Read more.
The use of cisplatin as a chemotherapeutic drug is impeded by the development of drug resistance. Combination therapies of a chemosensitizer for cisplatin have been studied, but with little success, and the search for an effective combination therapy is continuing. Our earlier reports have shown that Zanthoxylum armatum DC. extract enhances the apoptotic effect of cisplatin in cancer cell lines. In this study, we purified and identified the bioactive phytocompound through bio-assay-guided purification, using column chromatography and HPLC. Chemical characterization using NMR and mass spectrometry revealed the compound as planispine A, with molecular structure C25H30O6 and molecular weight, 426.16 g/mol. Planispine A was found to inhibit cancer cell proliferation in a dose-dependent manner and to sensitize the cancer cells to cisplatin-augmented apoptotic cell death, in a caspase-dependent manner. A combination of planispine A and cisplatin induced S-phase cell cycle arrest, and reduced the expression of survival proteins such as cyclin D1. Interestingly, planispine A inhibits the Fanconi anemia pathway, as shown by reduced FANCD2 foci formation and FANCD2 monoubiquitination, which revealed the molecular mechanism of chemo-sensitization of cancer cells to cisplatin. Evaluation of this combination therapy in cisplatin-resistant tumors may lead to more efficient cisplatin treatment. Full article
(This article belongs to the Special Issue Bioactive Compounds in Pharmaceutical Research)
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Review

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24 pages, 1075 KiB  
Review
Extraction, Isolation of Bioactive Compounds and Therapeutic Potential of Rapeseed (Brassica napus L.)
by Nazym Tileuberdi, Aknur Turgumbayeva, Balakyz Yeskaliyeva, Lazzat Sarsenova and Raushan Issayeva
Molecules 2022, 27(24), 8824; https://doi.org/10.3390/molecules27248824 - 12 Dec 2022
Cited by 9 | Viewed by 2549
Abstract
Rapeseed (Brassica napus L.) is a herbaceous annual plant of the Cruciferous family, the Cabbage genus. This oilseed crop is widely used in many areas of industry and agriculture. High-quality oil obtained from rapeseed can be found in many industrial food products. [...] Read more.
Rapeseed (Brassica napus L.) is a herbaceous annual plant of the Cruciferous family, the Cabbage genus. This oilseed crop is widely used in many areas of industry and agriculture. High-quality oil obtained from rapeseed can be found in many industrial food products. To date, extracts with a high content of biologically active substances are obtained from rapeseed using modern extraction methods. Brassica napus L. seeds contain polyunsaturated and monounsaturated fatty acids, carotenoids, phytosterols, flavonoids, vitamins, glucosinolates and microelements. The data in this review show that rapeseed biocompounds have therapeutic effects in the treatment of various types of diseases. Some studies indicate that rapeseed can be used as an anti-inflammatory, antioxidant, antiviral, hypoglycemic and anticancer agent. In the pharmaceutical industry, using rapeseed as an active ingredient may help to develop new forms drugs with wide range of therapeutic effects. This review focuses on aspects of the extraction of biocompounds from rapeseed and the study of its pharmacological properties. Full article
(This article belongs to the Special Issue Bioactive Compounds in Pharmaceutical Research)
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