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Identification and Characterization of Phenolic Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3199

Special Issue Editors


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Guest Editor
Department of Food Technology, Adana Alparslan Turkes Science and Technology University, 01250 Adana, Turkey
Interests: food chemistry; phenolic compounds; antioxidant activity; method development; instrumental analysis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Food Engineering, Faculty of Agriculture, Cukurova University, 1330 Adana, Turkey
Interests: food chemistry; volatile compounds; key odorants; phenolic compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phenolic compounds, also known as polyphenols, have piqued the interest of researchers and industrial producers in the last two decades, as witnessed by the number of publications spanning a wide variety of sector fields. Polyphenols are of great interest partly due to their widespread presence in fruit and vegetables, acting as dietary antioxidants capable of offering protection against oxidative stress and counteracting many diseases, including diabetes, aging, cancer, neurodegenerative and cardiovascular diseases, and actively playing a role in health maintenance. Now, we have a better understanding of phenolics’ profile in plants and plant-derived foods due to the ongoing advances in analytical chemistry; even so, this topic is yet to be further studied to increase our knowledge concerning the structures and interactions of polyphenols under different processes.

This Special Issue aims to present the most recent research regarding the chemistry, extraction methods, and analytical techniques surrounding polyphenols, along with their biological activities. Studies on novel approaches in the sample preparation, chromatographic separation, and detection of phenolics, including hyphenated techniques, such as LC-ion mobility mass spectrometry and LC-NMR spectroscopy, and research in regard to the characterization of novel structures, reaction mechanisms, and the synthesis of phenolic metabolites are also highly welcome.

We would like to invite researchers to participate in this Special Issue by submitting a contribution in their field of expertise. Studies with multidisciplinary inputs, offering novel methodologies or insights, are particularly welcome.

Dr. Hasim Kelebek
Dr. Serkan Selli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced analytical methodologies for the isolation, purification, and analysis of phenolics from food, food wastes, and medicinal plants
  • phenolic compounds and metabolites in plants, food, and biological samples
  • biological activities and mechanisms of action
  • health benefits
  • in vitro evaluation
  • development of novel antioxidants
  • phenolics-based nutraceuticals and functional ingredients

Published Papers (2 papers)

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Research

22 pages, 2338 KiB  
Article
New Type of Tannins Identified from the Seeds of Cornus officinalis Sieb. et Zucc. by HPLC-ESI-MS/MS
by Jun Li, Lin Chen, Hua Jiang, Min Li, Lu Wang, Jia-Xing Li, Yue-Yue Wang and Qing-Xia Guo
Molecules 2023, 28(5), 2027; https://doi.org/10.3390/molecules28052027 - 21 Feb 2023
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Abstract
There is a lack of information on the compound profile of Cornus officinalis Sieb. et Zucc. seeds. This greatly affects their optimal utilization. In our preliminary study, we found that the extract of the seeds displayed a strong positive reaction to the FeCl [...] Read more.
There is a lack of information on the compound profile of Cornus officinalis Sieb. et Zucc. seeds. This greatly affects their optimal utilization. In our preliminary study, we found that the extract of the seeds displayed a strong positive reaction to the FeCl3 solution, indicating the presence of polyphenols. However, to date, only nine polyphenols have been isolated. In this study, HPLC-ESI-MS/MS was employed to fully reveal the polyphenol profile of the seed extracts. A total of 90 polyphenols were identified. They were classified into nine brevifolincarboxyl tannins and their derivatives, 34 ellagitannins, 21 gallotannins, and 26 phenolic acids and their derivatives. Most of these were first identified from the seeds of C. officinalis. More importantly, five new types of tannins were reported for the first time: brevifolincarboxyl-trigalloyl-hexoside, digalloyl-dehydrohexahydroxydiphenoyl (DHHDP)-hexdside, galloyl-DHHDP-hexoside, DHHDP-hexahydroxydiphenoyl(HHDP)-galloyl-gluconic acid, and peroxide product of DHHDP-trigalloylhexoside. Moreover, the total phenolic content was as high as 79,157 ± 563 mg gallic acid equivalent per 100 g in the seeds extract. The results of this study not only enrich the structure database of tannins, but also provide invaluable aid to its further utilization in industries. Full article
(This article belongs to the Special Issue Identification and Characterization of Phenolic Compounds)
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11 pages, 573 KiB  
Article
Heliotropium procubens Mill: Taxonomic Significance and Characterization of Phenolic Compounds via UHPLC–HRMS- In Vitro Antioxidant and Enzyme Inhibitory Activities
by Kalliopi-Maria Ozntamar-Pouloglou, Antigoni Cheilari, Gokhan Zengin, Konstantia Graikou, Christos Ganos, George-Albert Karikas and Ioanna Chinou
Molecules 2023, 28(3), 1008; https://doi.org/10.3390/molecules28031008 - 19 Jan 2023
Cited by 2 | Viewed by 1445
Abstract
The aim of the present study was the phytochemical analysis of the aerial parts of Heliotropium procumbens Mill., a herb from Boraginaceae plant family not previously studied. The methanol (ME) and aqueous extracts (WE) of the aerial parts were assayed for their total [...] Read more.
The aim of the present study was the phytochemical analysis of the aerial parts of Heliotropium procumbens Mill., a herb from Boraginaceae plant family not previously studied. The methanol (ME) and aqueous extracts (WE) of the aerial parts were assayed for their total phenolic and flavonoid content and antioxidant properties, using free radical scavenging (DPPH, ABTS), reducing power (FRAP, CUPRAC), phosphomolybdenum and metal chelating assays. The extracts displayed considerable free radical scavenging activity against DPPH and ABTS radicals, with potential values of 46.88 and 68.31 mg TE/g extract for ME, and 93.43 and 131.48 mg TE/g extract for WE, respectively. Key clinical enzymes involved in neurodegenerative diseases AChE and BChE, diabetes (α-amylase and α-glucosidase) and skin whitening (tyrosinase) were also assayed. The phytochemical profile of the studied species was determined through UHPLC–HRMS, whereby 26 secondary metabolites were identified, three of which (luteolin-7-glucoside, lithospermic and rosmarinic acids) were isolated and structurally determined by NMR spectral means. H. procubens was found to harbor bioactive metabolites and could, hence, serve as a source of biological activities which could be further explored and exploited for potential applications. Full article
(This article belongs to the Special Issue Identification and Characterization of Phenolic Compounds)
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