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Selected papers from the 6th International Symposium on Phytochemicals in...
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Selected papers from the 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF, Hangzhou, 2022)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 4036

Special Issue Editors

Prof. Dr. Jianbo Xiao

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Guest Editor
Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Universidade de Vigo, Ourense Campus, E-32004 Ourense, Spain
Interests: phytochemicals; polyphenols; diabetes; function food; natural products; glycosylation; biological activity; flavonoids; stilbenoids; pharmacokinetics; nutrition and metabolism; polyphenol-protein interaction
Special Issues, Collections and Topics in MDPI journals
Dr. Fang Wang

E-Mail Website
Guest Editor
School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, China
Interests: food nutrition; active polypeptide; active polysaccharide; diabetes; obesity; molecular nutrition
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Wai San Cheang

E-Mail Website
Guest Editor
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China
Interests: natural products; vascular diseases; metabolic disorders; pharmacology; biological activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products can be obtained from plants, marine organisms and various microorganisms, and have been gaining extensive attention for their ability to promote health and to treat diseases. An increasing number of promising findings on the bioactivities and therapeutic potentials of natural products are published every year. Although there are existing therapeutic options, there is an ongoing need for novel therapies based on existing and emerging knowledge of the underlying disease mechanisms. Natural products, such as food supplements, spices, herbal medicines, marine products, and other products, represent an important source of drug discovery. We are guest editing this Special Issue to celebrate the 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF) in Hangzhou, China (2022.8.5-2022.8.10). This Special Issue welcomes the submission of manuscripts that address the recent advances and provide novel findings on the molecular pharmacology of natural products and human health.

6-ISPMF website: https://529324562.wixsite.com/6-ispmf

Original communications may be related to the usefulness of previous known or novel natural products in the treatment and management of diseases with clear molecular pharmacological investigations in in vitro and/or in vivo experimental models. The natural products can be extracts, fractions, and isolated compounds from a wide range of natural sources, but well-characterized preparations and a clear connection to the biological/therapeutic effects should be provided. Critical and comprehensive reviews on topics within the field of natural product pharmacology are highly welcome.

Contributions need not be limited to the fields mentioned in the keywords. We look forward to your contribution.

Prof. Dr. Jianbo Xiao
Dr. Fang Wang
Dr. Anna Wai San Cheang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • molecular pharmacology
  • molecular biology
  • mechanism of action
  • structure–activity relationship
  • therapeutic effects
  • bioactivity assessment

Published Papers (2 papers)

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Research

16 pages, 2704 KiB  
Article
Exploration of Antimicrobial Ingredients in Psoralea corylifolia L. Seed and Related Mechanism against Methicillin-Resistant Staphylococcus aureus
by Liqiong Sun, Zhijuan Tang, Minxin Wang, Jun Shi, Yajuan Lin, Tiefeng Sun, Zhilu Zou and Zebin Weng
Molecules 2022, 27(20), 6952; https://doi.org/10.3390/molecules27206952 - 17 Oct 2022
Cited by 3 | Viewed by 1436
Abstract
With the abuse of antibiotics, bacterial antibiotic resistance is becoming a major public healthcare issue. Natural plants, especially traditional Chinese herbal medicines, which have antibacterial activity, are important sources for discovering potential bacteriostatic agents. This study aimed to develop a fast and reliable [...] Read more.
With the abuse of antibiotics, bacterial antibiotic resistance is becoming a major public healthcare issue. Natural plants, especially traditional Chinese herbal medicines, which have antibacterial activity, are important sources for discovering potential bacteriostatic agents. This study aimed to develop a fast and reliable method for screening out antimicrobial compounds targeting the MRSA membrane from Psoralea corylifolia Linn. seed. A UPLC-MS/MS method was applied to identify the prenylated flavonoids in major fractions from the extracts of Psoralea corylifolia Linn. seed. The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of different fractions and compounds. The morphological and ultrastructural changes of MRSA were determined by scanning electron microscopy (SEM). The membrane-targeting mechanism of the active ingredients was explored by membrane integrity assays, membrane fluidity assays, membrane potential assays, ATP, and ROS determination. We identified eight prenylated flavonoids in Psoralea corylifolia Linn. seed. The antibacterial activity and mechanism studies showed that this type of compound has a unique destructive effect on MRSA cell membranes and does not result in drug resistance. The results revealed that prenylated flavonoids in Psoralea corylifolia Linn. seeds are promising candidates for the development of novel antibiotic agents to combat MRSA-associated infections. Full article
(This article belongs to the Special Issue Selected papers from the 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF, Hangzhou, 2022))
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14 pages, 2768 KiB  
Article
Research on ACEI of Low-Molecular-Weight Peptides from Hirudo nipponia Whitman
by Zhao Ding, Keli Chen and Yunzhong Chen
Molecules 2022, 27(17), 5421; https://doi.org/10.3390/molecules27175421 - 24 Aug 2022
Viewed by 1349
Abstract
The renin-angiotensin system (RAS) is the primary pathway for regulating blood pressure in the body, and angiotensin-converting enzymes (ACEs) play a crucial role in it. Hirudo nipponia is an invertebrate that contains a variety of active peptides; however, there are no studies on [...] Read more.
The renin-angiotensin system (RAS) is the primary pathway for regulating blood pressure in the body, and angiotensin-converting enzymes (ACEs) play a crucial role in it. Hirudo nipponia is an invertebrate that contains a variety of active peptides; however, there are no studies on the ACE inhibitory activity of hirudo. In the present study, our aim was to identify the active peptides in hirudo based on active peptide database analysis, unexpectedly filling the gap in hirudo ACE inhibitory activity research. Prep-HPLC was used to separate the part below 3 kD from hirudo. The peptide composition of the isolates was obtained based on Orbitrap LC-MS. The activity of each group of peptides was predicted by the database and the activity was determined by bioassay. Peptides with validation activity were screened through the database. In total, 337 peptides and 18 peptides matching the NCBI leech protein database were identified. All four fractions showed ACE inhibitory activity, and the IC50 was 0.8266, 0.2708, 0.4432, and 0.1764 mg/mL, respectively. Six screened peptides showed good affinity for ACE. This work reveals for the first time that low-molecular-weight peptides from H. nipponia have ACE inhibitory activity, which can provide a new explanation for leech treatment of hypertension. Full article
(This article belongs to the Special Issue Selected papers from the 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF, Hangzhou, 2022))
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