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Marine Bioactives for Human Health
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Marine Bioactives for Human Health

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1605

Special Issue Editor

Dr. Benoît Chénais

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Guest Editor
BiOSSE, Biology of Organisms, Health, Stress, Environment, UFR Sciences et Techniques, Le Mans Université, 72085 Le Mans, CEDEX 9, France
Interests: cancer cell biology; DNA repair; transposable elements; bioactive molecules; gene expression; stress response; microalgae; polyunsaturated fatty acids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The marine world represents considerable biodiversity and chemodiversity that is still insufficiently explored and exploited. While several examples of molecules or species of marine origin (particularly sponges, algae and microalgae) are known for their uses in human healthcare, cosmetics and the food industry, many others remain insufficiently studied or have yet to be discovered. The aim of this Special Issue is to provide an opportunity to present the molecular and functional characterization of new molecules of marine origin, describe the mechanism of action of new or older marine bioactives at the molecular, cellular or in vivo levels, and offer summaries of the current state of the knowledge in this field. Therefore, original research papers and review papers are welcome.

Dr. Benoît Chénais
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive molecules
  • marine organisms
  • polyunsaturated fatty acids
  • pigments
  • polyphenols
  • sterol derivatives
  • glycanes and glycoconjugate
  • cardiovascular disease
  • cancer
  • metabolic syndrome
  • inflammation
  • angiogenesis
  • antioxidant

Published Papers (2 papers)

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Research

15 pages, 4342 KiB  
Article
Understanding Antidiabetic Potential of Oligosaccharides from Red Alga Dulse Devaleraea inkyuleei Xylan by Investigating α-Amylase and α-Glucosidase Inhibition
by Martin Alain Mune Mune, Tadashi Hatanaka, Hideki Kishimura and Yuya Kumagai
Molecules 2024, 29(7), 1536; https://doi.org/10.3390/molecules29071536 - 29 Mar 2024
Viewed by 615
Abstract
In this study, the α-glucosidase (maltase-glucoamylase: MGAM) and α-amylase inhibitory properties elicited by xylooligosaccharides (XOSs) prepared from dulse xylan were analysed as a potential mechanism to control postprandial hyperglycaemia for type-2 diabetes prevention and treatment. Xylan was purified from red alga dulse powder [...] Read more.
In this study, the α-glucosidase (maltase-glucoamylase: MGAM) and α-amylase inhibitory properties elicited by xylooligosaccharides (XOSs) prepared from dulse xylan were analysed as a potential mechanism to control postprandial hyperglycaemia for type-2 diabetes prevention and treatment. Xylan was purified from red alga dulse powder and used for enzymatic hydrolysis using Sucrase X to produce XOSs. Fractionation of XOSs produced xylobiose (X2), β-(1→3)-xylosyl xylobiose (DX3), xylotriose (X3), β-(1→3)-xylosyl-xylotriose (DX4), and a dulse XOS mixture with n ≥ 4 xylose units (DXM). The different fractions exhibited moderate MGAM (IC50 = 11.41–23.44 mg/mL) and α-amylase (IC50 = 18.07–53.04 mg/mL) inhibitory activity, which was lower than that of acarbose. Kinetics studies revealed that XOSs bound to the active site of carbohydrate digestive enzymes, limiting access to the substrate by competitive inhibition. A molecular docking analysis of XOSs with MGAM and α-amylase clearly showed moderate strength of interactions, both hydrogen bonds and non-bonded contacts, at the active site of the enzymes. Overall, XOSs from dulse could prevent postprandial hyperglycaemia as functional food by a usual and continuous consumption. Full article
(This article belongs to the Special Issue Marine Bioactives for Human Health)
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18 pages, 24160 KiB  
Article
Revealing Novel Source of Breast Cancer Inhibitors from Seagrass Enhalus acoroides: In Silico and In Vitro Studies
by Yan Wisnu Prajoko, Faqrizal Ria Qhabibi, Timothy Sahala Gerardo, Kanandya Kizzandy, Krisanto Tanjaya, Sebastian Emmanuel Willyanto, Happy Kurnia Permatasari, Reggie Surya, Nelly Mayulu, Nurpudji Astuti Taslim, Raymond Rubianto Tjandrawinata, Rony Abdi Syahputra, Trina Ekawati Tallei, Apollinaire Tsopmo, Bonglee Kim, Rudy Kurniawan and Fahrul Nurkolis
Molecules 2024, 29(5), 1082; https://doi.org/10.3390/molecules29051082 - 29 Feb 2024
Viewed by 832
Abstract
Enhalus arcoides is a highly beneficial type of seagrass. Prior studies have presented proof of the bioactivity of E. acoroides, suggesting its potential to combat cancer. Therefore, this study aims to delve deeper into E. acoroides bioactive molecule profiles and their direct [...] Read more.
Enhalus arcoides is a highly beneficial type of seagrass. Prior studies have presented proof of the bioactivity of E. acoroides, suggesting its potential to combat cancer. Therefore, this study aims to delve deeper into E. acoroides bioactive molecule profiles and their direct biological anticancer activities potentials through the combination of in-silico and in-vitro studies. This study conducted metabolite profile analysis on E. acoroides utilizing HPLC-ESI-HRMS/MS analysis. Two extraction techniques, ethanol and hexane, were employed for the extraction process. Furthermore, the in-silico study was conducted using molecular docking simulations on the HER2, EGFR tyrosine kinase and HIF-1α protein receptor. Afterward, the antioxidant activity of E. acoroides metabolites was examined to ABTS, and the antiproliferative activity was tested using an MTT assay. An in-silico study revealed its ability to combat breast cancer by inhibiting the HER2/EGFR/HIF-1α pathway through molecular docking. In addition, the MTT assay demonstrated that higher dosages of metabolites from E. acoroides increased the effectiveness of toxicity against cancer cell lines. Additionally, the study demonstrated that the metabolites possess the ability to function as potent antioxidants, effectively inhibiting a series of carcinogenic mechanisms. Ultimately, this study showed a new approach to unveiling the E. acoroides metabolites’ anticancer activity through inhibiting HER2/EGFR/HIF-1α receptors, with great cytotoxicity and a potent antioxidant property to prevent a carcinogenic cascade. Full article
(This article belongs to the Special Issue Marine Bioactives for Human Health)
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