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Biomedical Applications of Infrared and Raman Spectroscopy II

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Photochemistry".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 954

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
1. Department of Chemistry, Coimbra Chemistry Center, University of Coimbra, Coimbra, Portugal
2. Faculty of Sciences & Letters, Department of Physics, Istanbul Kultur University, Istanbul, Turkey
Interests: photochemistry; molecular cryo- and biospectroscopy; quantum chemistry; molecular structure; photophysics; chemometrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my great pleasure to invite you to submit an article for a high-profile Special Issue on “Biomedical Applications of Infrared and Raman Spectroscopy II” to be published in Molecules.

Infrared and Raman spectroscopy have been gaining interest as tools to address complex problems in biomedicine. The basis for this is that both infrared and Raman techniques are capable of providing particulars of the morphology and chemical composition of cells, tissues, and other biomaterials, in a fast non-destructive way, but are also able to scrutinize fine details of the structures adopted by their constituting molecules. Since diseases and other pathological anomalies lead to chemical and structural changes at the molecular level, vibrational spectra can be used as sensitive phenotypic markers of the diseases. At present, with the handiness of high-throughput and sensitive instruments for Raman and infrared microspectroscopic imaging, reliable fiber-optical probes for in vivo applications, and powerful analytical methods based on multivariate analysis, all conditions exist for infrared and Raman spectroscopy to gain prominence in the biomedical field.

Research articles on both technical developments and applications of infrared and Raman spectroscopy to biomedical problems are welcome, as are review articles and perspectives from experts in the field.

Prof. Dr. Rui Fausto
Prof. Dr. Gulce Ogruc Ildiz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Raman spectroscopy
  • infrared spectroscopy
  • biomedical applications
  • chemometrics

Published Papers (1 paper)

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Research

12 pages, 4358 KiB  
Article
Raman Spectroscopy and Cystic Fibrosis Disease: An Alternative Potential Tool for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Response Differentiation—A Pilot Study Based on Serum Samples
by Giuseppe Acri, Barbara Testagrossa, Maria Cristina Lucanto, Simona Cristadoro, Salvatore Pellegrino, Elisa Ruello and Stefano Costa
Molecules 2024, 29(2), 433; https://doi.org/10.3390/molecules29020433 - 16 Jan 2024
Viewed by 674
Abstract
Cystic fibrosis (CF) is a genetic disorder that alters chloride transport in mucous membranes. Recent studies have demonstrated that treatment with modulators of the chloride channel reduces inflammatory markers, restoring, among others, the imbalance of lipids. In this study, we analyzed the serum [...] Read more.
Cystic fibrosis (CF) is a genetic disorder that alters chloride transport in mucous membranes. Recent studies have demonstrated that treatment with modulators of the chloride channel reduces inflammatory markers, restoring, among others, the imbalance of lipids. In this study, we analyzed the serum samples of treated and non-treated patients with modulators with Raman spectroscopy. Nineteen (eight treated an eleven non-treated) patients were considered. The main difference between the two groups appeared in the 3020–2800 cm−1 range. A Voigt deconvolution fit was performed, and nine sub-bands were identified. To distinguish between treated and non-treated patients, the area ratio between the CH3 and CH2 vibration modes was calculated for each patient. The results were validated using statistical analyses. In particular, receiver operating characteristic (ROC) curves and Youden index (Y) were calculated (Area Under Curve (AUC): 0.977; Y: 3.30). An ROC curve represents the performance of the classification, illustrating the diagnostic ability of Raman spectroscopy. It was demonstrated that Raman spectroscopy is able to highlight peculiar differences between elexacaftor/tezacaftor/ivacaftor (ETI)-treated and non-treated patients, in relation with lipids biomarkers. Full article
(This article belongs to the Special Issue Biomedical Applications of Infrared and Raman Spectroscopy II)
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