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Molecules
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Synthesis and Biological Activities of Natural Products and Their Derivatives
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Synthesis and Biological Activities of Natural Products and Their Derivatives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3112

Special Issue Editors

Prof. Dr. Qingmin Wang

E-Mail Website
Guest Editor
Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China
Interests: drug discovery
Dr. Ziwen Wang

E-Mail Website
Guest Editor
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
Interests: natural products; botanical pesticides; total synthesis; pesticide lead discovery; plant disease and pest control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the increasing prevalence of pests, bacterial, fungal and viral infections and the ability of these pathogens to develop resistance to current pesticides and drugs, there is a great need to find new compounds to combat them. Natural products (NPs) are the metabolites of animals or plants, which have the advantages of biocompatibility, structural diversity, and unique mechanism. The screening of active structures with promising biological competence from NPs is a high-efficiency and achievable method for the development of pesticide and drug alternatives. 

In this Special Issue, we invite researchers to contribute original research or review articles on topics related to all aspects of the synthesis, structural simplification and biological activity studies of natural products, including, but not limited to, the discovery of natural bio-active lead compounds, total synthesis, structural modification and activity evaluation, structure-activity relationship, mechanism study and target identification, biogenic nano drug, biogenic nano pesticide, etc.

Prof. Dr. Qingmin Wang
Dr. Ziwen Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural product
  • total synthesis
  • structural simplification
  • pesticide candidate discovery
  • drug candidate discovery
  • structure-activity relationship
  • mechanism study and target identification

Published Papers (2 papers)

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Research

21 pages, 11592 KiB  
Article
Microbial Diversity and Enzyme Activity as Indicators of Permethrin-Exposed Soil Health
by Agata Borowik, Jadwiga Wyszkowska, Magdalena Zaborowska and Jan Kucharski
Molecules 2023, 28(12), 4756; https://doi.org/10.3390/molecules28124756 - 14 Jun 2023
Cited by 2 | Viewed by 1125
Abstract
Owing to their wide range of applications in the control of ticks and insects in horticulture, forestry, agriculture and food production, pyrethroids pose a significant threat to the environment, including a risk to human health. Hence, it is extremely important to gain a [...] Read more.
Owing to their wide range of applications in the control of ticks and insects in horticulture, forestry, agriculture and food production, pyrethroids pose a significant threat to the environment, including a risk to human health. Hence, it is extremely important to gain a sound understanding of the response of plants and changes in the soil microbiome induced by permethrin. The purpose of this study has been to show the diversity of microorganisms, activity of soil enzymes and growth of Zea mays following the application of permethrin. This article presents the results of the identification of microorganisms with the NGS sequencing method, and of isolated colonies of microorganisms on selective microbiological substrates. Furthermore, the activity of several soil enzymes, such as dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline phosphatase (Pal), β-glucosidase (Glu) and arylsulfatase (Aryl), as well as the growth of Zea mays and its greenness indicators (SPAD), after 60 days of growth following the application of permethrin, were presented. The research results indicate that permethrin does not have a negative effect on the growth of plants. The metagenomic studies showed that the application of permethrin increases the abundance of Proteobacteria, but decreases the counts of Actinobacteria and Ascomycota. The application of permethrin raised to the highest degree the abundance of bacteria of the genera Cellulomonas, Kaistobacter, Pseudomonas, Rhodanobacter and fungi of the genera Penicillium, Humicola, Iodophanus, Meyerozyma. It has been determined that permethrin stimulates the multiplication of organotrophic bacteria and actinomycetes, decreases the counts of fungi and depresses the activity of all soil enzymes in unseeded soil. Zea mays is able to mitigate the effect of permethrin and can therefore be used as an effective phytoremediation plant. Full article
(This article belongs to the Special Issue Synthesis and Biological Activities of Natural Products and Their Derivatives)
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15 pages, 2057 KiB  
Article
Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
by Kaihua Wang, Beibei Wang, Henan Ma, Ziwen Wang, Yuxiu Liu and Qingmin Wang
Molecules 2023, 28(8), 3328; https://doi.org/10.3390/molecules28083328 - 09 Apr 2023
Cited by 3 | Viewed by 1607
Abstract
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and [...] Read more.
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds I, I-1e and II-1a emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC50 values: 11.35–17.70 µg/mL) against Cercospora, arachidicola Hori. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds I-1f and II-1f showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds II-1d and III-1c displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against Plutella xylostella. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. Full article
(This article belongs to the Special Issue Synthesis and Biological Activities of Natural Products and Their Derivatives)
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