Nutrition and the Ageing Brain

A special issue of Medical Sciences (ISSN 2076-3271).

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 7812

Special Issue Editors


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Guest Editor
USDA-ARS, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Interests: biology of ageing; behavioural neuroscience; neuroinflammation; neurovascular health; age-related cognitive decline; neurodegeneration

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Guest Editor
USDA-ARS, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Interests: biology of ageing; evolutionary mismatch; nutritional neuroscience; neuroinflammation; neurovascular health; age-related cognitive decline; neurodegeneration
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Special Issue Information

Dear Colleagues,

As populations in developed countries continue to get older, age-associated decrements in mobility and cognition will become increasingly prevalent. Strategies to slow or reverse these deficits are needed to increase healthy aging and reduce health care costs. Foods such as nuts, berries and other fruits have been shown to reduce the risk of age-related cognitive impairment in model organisms and humans. However, more research is needed to further identify specific dietary components that preserve cognition and overall brain health. In addition, more work must be completed to identify the mechanisms of action underlying improvements in cognition and overall brain health including studying neuroinflammation, neurovascular function, the gut-brain axis and other related pathways.

Researchers in the field are cordially invited to contribute original research papers or reviews to this Special issue of Molecules, which aims to identify nutritional interventions that help improve brain health, including cognition, mobility, and risk of neurodegenerative disorders and the mechanisms that underly these improvements. We look forward to reading your manuscripts.

You may choose our Joint Special Issue in Molecules.

Dr. Barbara Shukitt-Hale
Dr. Grant A. Rutledge
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medical Sciences is an international peer-reviewed open access quarterly journal published by MDPI.

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Keywords

  • aging
  • nutrition
  • cognition
  • neurodegeneration
  • neuroinflammation
  • polyphenols

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Published Papers (1 paper)

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Review

15 pages, 639 KiB  
Review
Nutrients, Cognitive Function, and Brain Aging: What We Have Learned from Dogs
by Yuanlong Pan
Med. Sci. 2021, 9(4), 72; https://doi.org/10.3390/medsci9040072 - 18 Nov 2021
Cited by 4 | Viewed by 7270
Abstract
Due to a difference in genetics, environmental factors, and nutrition, just like in people, dogs age at different rates. Brain aging in people and dogs share similar morphological changes including irreversible cortical atrophy, cerebral amyloid angiopathy, and ventricular enlargement. Due to severe and [...] Read more.
Due to a difference in genetics, environmental factors, and nutrition, just like in people, dogs age at different rates. Brain aging in people and dogs share similar morphological changes including irreversible cortical atrophy, cerebral amyloid angiopathy, and ventricular enlargement. Due to severe and irreversible brain atrophy, some aging dogs develop cognitive dysfunction syndrome (CDS), which is equivalent to dementia or Alzheimer’s disease (AD) in people. The risk factors and causes of CDS in dogs have not been fully investigated, but age, gender, oxidative stress, and deficiency of sex hormones appears to be associated with increased risk of accelerated brain aging and CDS in dogs. Both AD and CDS are incurable diseases at this moment, therefore more efforts should be focused on preventing or reducing brain atrophy and minimizing the risk of AD in people and CDS in dogs. Since brain atrophy leads to irreversible cognitive decline and dementia, an optimal nutritional solution should be able to not only enhance cognitive function during aging but also reduce irreversible brain atrophy. Up to now, only one nutritional intervention has demonstrated both cognition-enhancing benefits and atrophy-reducing benefits. Full article
(This article belongs to the Special Issue Nutrition and the Ageing Brain)
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