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Special Issue "Marine Natural Products as a Source of Analgesics"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3080

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Dr. Yaroslav Andreev

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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia
Interests: neuronal receptors; peptides; biologically active substances; neurons; inflammation; pain; recombinant proteins; ASIC channels; TRP channels; antimicrobial peptides

Special Issue Information

Dear Colleagues,

Pain is an essential part of life that is too hard to tolerate in some cases. So far, the most effective drugs are narcotic analgesics that cause addiction accompanied by the necessity of dose increase. Marine natural products contain a variety of biologically active compounds of different nature (proteins, peptides, small molecules, etc.) that can produce analgesic and anti-inflammatory effects. Such compounds are very important for the development of analgesic drugs.

This Special Issue on “Marine Natural Products as a Source of Analgesics” will include the latest scientific research in the isolation, characterization, and development of marine natural products with analgesic properties. The manuscript should include structural characterization of compounds, in vitro studies confirming their molecular target(s,) and in vivo evaluation of analgesic effects that are not compromised by toxicity or sedation. Additionally, novel cellular and animal models for analgesic compounds screening and analysis are welcome. Reviews and research papers will be considered for publication.

Dr. Yaroslav Andreev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

marine natural products
analgesics
anti-pain
molecular target
structural characterization
in vitro
in vivo

Published Papers (2 papers)

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Research

Open AccessArticle

Antinociceptive Effects of Aaptamine, a Sponge Component, on Peripheral Neuropathy in Rats

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Mar. Drugs 2023, 21(2), 113; https://doi.org/10.3390/md21020113 - 04 Feb 2023

Cited by 1 | Viewed by 1176

Abstract

Aaptamine, a natural marine compound isolated from the sea sponge, has various biological activities, including delta-opioid agonist properties. However, the effects of aaptamine in neuropathic pain remain unclear. In the present study, we used a chronic constriction injury (CCI)-induced peripheral neuropathic rat model to explore the analgesic effects of intrathecal aaptamine administration. We also investigated cellular angiogenesis and lactate dehydrogenase A (LDHA) expression in the ipsilateral lumbar spinal cord after aaptamine administration in CCI rats by immunohistofluorescence. The results showed that aaptamine alleviates CCI-induced nociceptive sensitization, allodynia, and hyperalgesia. Moreover, aaptamine significantly downregulated CCI-induced vascular endothelial growth factor (VEGF), cluster of differentiation 31 (CD31), and LDHA expression in the spinal cord. Double immunofluorescent staining showed that the spinal VEGF and LDHA majorly expressed on astrocytes and neurons, respectively, in CCI rats and inhibited by aaptamine. Collectively, our results indicate aaptamine’s potential as an analgesic agent for neuropathic pain. Furthermore, inhibition of astrocyte-derived angiogenesis and neuronal LDHA expression might be beneficial in neuropathy. Full article

(This article belongs to the Special Issue Marine Natural Products as a Source of Analgesics)

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Open AccessArticle

Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel

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Mar. Drugs 2022, 20(7), 465; https://doi.org/10.3390/md20070465 - 21 Jul 2022

Cited by 1 | Viewed by 1291

Abstract

The TRPA1 channel is involved in a variety of physiological processes and its activation leads to pain perception and the development of inflammation. Peptide Ms 9a-1 from sea anemone Metridium senile is a positive modulator of TRPA1 and causes significant analgesic and anti-inflammatory effects by desensitization of TRPA1-expressing sensory neurons. For structural and functional analysis of Ms 9a-1, we produced four peptides—Ms 9a-1 without C-terminal domain (abbreviated as N-Ms), short C-terminal domain Ms 9a-1 alone (C-Ms), and two homologous peptides (Ms 9a-2 and Ms 9a-3). All tested peptides possessed a reduced potentiating effect on TRPA1 compared to Ms 9a-1 in vitro. None of the peptides reproduced analgesic and anti-inflammatory properties of Ms 9a-1 in vivo. Peptides N-Ms and C-Ms were able to reduce pain induced by AITC (selective TRPA1 agonist) but did not decrease AITC-induced paw edema development. Fragments of Ms 9a-1 did not effectively reverse CFA-induced thermal hyperalgesia and paw edema. Ms 9a-2 and Ms 9a-3 possessed significant effects and anti-inflammatory properties in some doses, but their unexpected efficacy and bell-shape dose–responses support the hypothesis of other targets involved in their effects in vivo. Therefore, activity comparison of Ms 9a-1 fragments and homologues peptides revealed structural determinants important for TRPA1 modulation, as well as analgesic and anti-inflammatory properties of Ms9a-1. Full article

(This article belongs to the Special Issue Marine Natural Products as a Source of Analgesics)

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