Pharmacological Models and Assays in Marine Drugs Evaluation
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (5 August 2021) | Viewed by 374
Special Issue Editors
Interests: anticancer compounds; heterocycles; melanoma; microalgae; natural products; pharmacology; pigments; tumor phototherapy
Special Issues, Collections and Topics in MDPI journals
Interests: phycology; marine molecules; extraction eco-friendly processes; antiviral agents; SAR studies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Marine organisms are known to synthesise an exceptional diversity of natural products exhibiting diversified biological and pharmacological activities such as antiviral, antibacterial, anti-neurodegenerative, anti-inflammatory, antiobesity, and cytotoxic activities. The demonstration of these activities requires the development and validation of relevant and reproducible pharmacological models and assays useful for standardizing methodological approaches and providing international standards for data comparison. However, the identification of new cellular and molecular targets, including recently discovered signalling pathways and metabolic targets, also requires the development of cutting-edge molecular, cellular, tissue and animal models. Keeping a critical view of the methodological limitations of the models and assays is important to avoid the overinterpretation of data and guarantee the validity of the models to evidence activity. One of the current major difficulties is efficiently and quickly screening and purifying bioactive marine natural products from complex matrices, without finding already-identified molecules for the targeted activity.
In this Special Issue, we invite you to discuss all aspects dealing with the development, use and critical evaluation of pharmacological models and assays for marine drugs. Particularly, we invite researchers developing original screening approaches such as ligand fishing in complex matrices, de-replication, multitarget/multidrug approaches, in vitro or in silico models, medium- and high-throughput screening platforms, strategy validation and decision-support tools to submit reviews and reports on their most recent and innovative work.
We hope that this Special Issue will provide a panoramic and in-depth overview of the state of the art and recent original research in the field of pharmacological models and assays for the evaluation of marine drugs, and hope that this Special Issue will become a useful database for selecting tests with high methodological quality to identify marine molecules with preclinical potential.
Dr. Laurent Picot
Prof. Dr. Nathalie Bourgougnon
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacological models
- pharmacological assays
- ligand fishing in complex matrices
- multitarget/multidrug approaches
- in vitro or in silico models
- medium- and high-throughput screening platforms
- strategy validation
- decision-support tools
- marine molecules
