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Marine Drugs
Special Issues
Marine Fucosylated Chondroitin Sulfates
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Special Issue "Marine Fucosylated Chondroitin Sulfates"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 306

Special Issue Editor

Dr. Shiwei Hu

E-Mail Website
Guest Editor
National Engineering Research Center for Maine Aquaculture, Zhejiang Ocean University, Zhoushan 316022, China
Interests: food science; marine bioactive substance; structure-function relationship
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Marine fucosylated chondroitin sulfates have become potential marine drugs or functional foods for arthrosis or several metabolic disorders, and are mainly isolated from fish cartilage, echinoderm, and skins. Notwithstanding the enormous efforts of academic researchers, numerous problems and difficulties also astrict the utilization of marine fucosylated chondroitin sulfates, including digestive absorption of the macromolecular polysaccharides, polysaccharide modifications, the novel structures and source of fucosylated chondroitin sulfates, structure–function relationships, etc. This Special Issue plans to give an overview of the most recent advances in the discovery of marine fucosylated chondroitin sulfates and their applications. This Special Issue is aimed at providing selected contributions on the aforementioned bottlenecks of marine fucosylated chondroitin sulfates’ development and application. Potential topics include, but are not limited to: novel structures of marine fucosylated chondroitin sulfates; chemical modifications on the structure of marine fucosylated chondroitin sulfates; new applications of marine fucosylated chondroitin sulfates; digestive absorption of marine fucosylated chondroitin sulfates in vivo; structure–function relationship of marine fucosylated chondroitin sulfates; future perspectives for marine fucosylated chondroitin sulfates

Dr. Shiwei Hu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fucosylated chondroitin sulfates
  • novel structure and source
  • chemical modifications
  • new applications
  • digestive absorption
  • structure–function relationship
  • future perspectives

Published Papers (1 paper)

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Research

13 pages, 2745 KiB  
Article
Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs
by
Shiwei Hu
,
Xiaofeng Wan
,
Hongli Zhu
and
Huicheng Yang
Mar. Drugs 2023, 21(11), 573; https://doi.org/10.3390/md21110573 - 31 Oct 2023
Viewed by 606
Abstract
Several sialoglycopeptides were isolated from several fish eggs and exerted anti-osteoporosis effects. However, few papers have explored sialoglycopeptide from tuna eggs (T-ES). Here, a novel T-ES was prepared through extraction with KCl solution and subsequent enzymolysis. Pure T-ES was obtained through DEAE-Sepharose ion [...] Read more.
Several sialoglycopeptides were isolated from several fish eggs and exerted anti-osteoporosis effects. However, few papers have explored sialoglycopeptide from tuna eggs (T-ES). Here, a novel T-ES was prepared through extraction with KCl solution and subsequent enzymolysis. Pure T-ES was obtained through DEAE-Sepharose ion exchange chromatography and sephacryl S-300 gel filtration chromatography. The T-ES was composed of 14.07% protein, 73.54% hexose, and 8.28% Neu5Ac, with a molecular weight of 9481 Da. The backbone carbohydrate in the T-ES was →4)-β-D-GlcN-(1→3)-α-D-GalN-(1→3)-β-D-Glc-(1→2)-α-D-Gal-(1→2)-α-D-Gal-(1→3)-α-D-Man-(1→, with two branches of β-D-GlcN-(1→ and α-D-GalN-(1→ linking at o-4 in →2,4)-α-D-Gal-(1→. Neu5Ac in the T-ES was linked to the branch of α-D-GlcN-(1→. A peptide chain, Ala-Asp-Asn-Lys-Ser*-Met-Ile that was connected to the carbohydrate chain through O-glycosylation at the –OH of serine. Furthermore, in vitro data revealed that T-ES could remarkably enhance bone density, bone biomechanical properties, and bone microstructure in SAMP mice. The T-ES elevated serum osteogenesis-related markers and reduced bone resorption-related markers in serum and urine. The present study’s results demonstrated that T-ES, a novel sialoglycopeptide, showed significant anti-osteoporosis effects, which will accelerate the utilization of T-ES as an alternative marine drug or functional food for anti-osteoporosis. Full article
(This article belongs to the Special Issue Marine Fucosylated Chondroitin Sulfates)
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