Therapies for Age-Linked Human Vascular Diseases Using In Vitro and In Vivo Models

Dear Colleagues,

Age-linked vascular diseases, such as atherosclerosis, hypertension, and vascular dementia, represent a growing health concern worldwide as the aging population continues to expand. Understanding the underlying mechanisms and developing effective therapies for these conditions is imperative for improving the quality of life in aging individuals. This research explores the potential of in vitro and in vivo models to study age-related vascular diseases and develop innovative therapeutic strategies. In vitro models, encompassing cell cultures and organoids, allow for the investigation of cellular and molecular mechanisms contributing to vascular aging. These models enable the screening of novel compounds and interventions as well as the assessment of their effects on cellular processes, including oxidative stress, inflammation, and endothelial dysfunction. Moreover, in vitro platforms provide a valuable means to simulate the aging process and evaluate candidate therapies prior to in vivo testing. In vivo models, including animal models and human clinical studies, offer insights into the systemic and physiological aspects of age-linked vascular diseases. Animal models can mimic various aspects of vascular aging, enabling the study of disease progression, interventions, and potential side effects of treatments. Clinical studies provide critical data on the safety and efficacy of therapies in humans, ultimately guiding their translation into clinical practice.

This Special Issue outlines the importance of integrating in vitro and in vivo models to comprehensively investigate age-related vascular diseases. By utilizing these models in tandem, researchers can identify promising therapeutic targets and interventions, bridge the gap between preclinical and clinical studies, and accelerate the development of innovative treatments for age-linked vascular diseases. Ultimately, this interdisciplinary approach holds great promise for addressing the healthcare challenges associated with an aging global population.

Dr. Pazhanichamy Kalailingam
Dr. Suresh Veeraperumal
Guest Editors

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