Advances in Personalized Diagnosis and Treatment in Dermatology

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 558

Special Issue Editor

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Guest Editor
1. Dermatology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy
2. Pediatric Dermatology Regional Center, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy
Interests: skin rare diseases; dermatoscopy of melanocytic lesions in children and adults; skin diseases in organ transplant recipients; clinical, epidemiological, immunological, and therapeutical investigations on contact and atopic dermatitis and pediatric psoriasis

Special Issue Information

Dear Colleagues,

Dermatology is rapidly advancing, and the focus on personalized diagnosis and treatment has never been more crucial.

The landscape of dermatology has been profoundly shaped by technological advancements and a deeper understanding of the genetic and environmental factors influencing skin diseases. Tracing the evolution of dermatologic treatments reveals a significant journey from one-size-fits-all approaches to tailored therapies.

The aim and scope of the Special Issue is to highlight innovative research and developments in personalized dermatologic diagnosis and treatment, emphasizing the importance of addressing the unique needs of each patient. Contributions should present groundbreaking findings in the diagnosis, treatment, and management of dermatologic conditions. Original research articles and innovative reviews focused on new insights in personalized dermatology are welcome.

Prof. Dr. Anna Belloni Fortina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • personalized dermatology
  • dermatological treatments
  • rare skin diseases
  • pediatric dermatology
  • dermatological care in organ transplant recipients
  • atopic dermatitis
  • contact sensitization
  • psoriasis
  • clinical and epidemiological studies in dermatology
  • immunological aspects of skin diseases
  • technological advancements in dermatology
  • tailored therapeutic strategies
  • pigmented lesions

Published Papers (1 paper)

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12 pages, 1128 KiB  
Systematic Review
Misdiagnosis and Clinical Insights into Acral Amelanotic Melanoma—A Systematic Review
by Fortunato Cassalia, Andrea Danese, Enrico Cocchi, Elisabetta Danese, Francesca Ambrogio, Gerardo Cazzato, Marcodomenico Mazza, Anna Zambello, Anna Belloni Fortina and Davide Melandri
J. Pers. Med. 2024, 14(5), 518; - 13 May 2024
Viewed by 435
Background: Acral amelanotic melanomas (AAMs), a rare subset of melanomas located on acral sites such as the palms, soles, and subungual areas, are diagnostically challenging due to their lack of typical pigmentation and often benign clinical appearance. Misdiagnosis is common, leading to delays [...] Read more.
Background: Acral amelanotic melanomas (AAMs), a rare subset of melanomas located on acral sites such as the palms, soles, and subungual areas, are diagnostically challenging due to their lack of typical pigmentation and often benign clinical appearance. Misdiagnosis is common, leading to delays in treatment and potentially worse outcomes. This systematic review aims to synthesise evidence on cases of AAM initially misdiagnosed as other conditions, to better understand their clinical and epidemiological characteristics, diagnostic pitfalls, and management strategies. Methods: A comprehensive search of the MEDLINE/PubMed, EMBASE, and SCOPUS databases was conducted up to March 2024. Case reports and small case series of AAMs initially misdiagnosed as other conditions were included. Data on patient demographics, clinical presentation, and diagnostic methods were collected and analyzed. Results: Of the 152 records identified, 26 cases from 23 articles met the inclusion criteria. A demographic analysis revealed that the gender distribution appears to be perfectly balanced, with an age range of 38 to 91 years. Misdiagnoses included non-healing ulcers or traumatic lesions (37.5%), benign proliferative lesions (29.2%) and infectious lesions (20.8%). The foot was the most affected site (53.8%). Notably, a histological evaluation was performed in 50% of cases involving the upper extremities, in contrast to only 7.1% of cases involving the foot and 0% of cases of the heel. This discrepancy suggests a reluctance to perform biopsies in the lower extremities, which may contribute to a higher misdiagnosis rate in these areas. Conclusions: The underutilization of biopsy in the diagnosis of lower extremity lesions contributes significantly to the misdiagnosis and delay in treatment of AAMs. Especially when the clinical assessment and dermoscopy are inconclusive, biopsies of suspicious lesions are essential. Immunohistochemistry and markers such as PRAME are critical in differentiating melanoma from other malignancies such as clear cell sarcoma. This review highlights the need for increased vigilance and a proactive diagnostic approach to increase early detection rates and improve prognostic outcomes. Full article
(This article belongs to the Special Issue Advances in Personalized Diagnosis and Treatment in Dermatology)
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