Dear Colleagues, 

We have seen a rapid advancement in molecular technologies and use of such methods in the daily practice of lung cancer pathology. Today, there are numerous approvals and ongoing trials for treatments linked to predictive molecular alterations or biomarkers in lung cancer.

For lung cancer investigations, the small size of typical samples (biopsies, cytology, and liquid-based samples) presents a major challenge to comprehensive molecular analysis. In addition to tumor material requirements and coverage, time and cost are also issues that may affect the choice of molecular methods in clinical practice.

Given the advances and increased knowledge in molecular pathology and tumor biology, molecular profiling in the future may contribute even more to subtyping/classification of tumors, distinguishing lung cancers from pulmonary metastases or benign/non-neoplastic lesions, and separation of synchronous lung cancers from intrapulmonary metastases, among others. Likewise, the role of molecular pathology in early detection, tumor heterogeneity, and progression and resistance mechanisms will likely expand.

We invite investigators to contribute original research articles as well as review articles and short communications. Potential topics include, but are not limited to, the following:

• discovery and/or validation of diagnostic or treatment-predictive molecular biomarkers;
• multiplex molecular techniques for histology, cytology, and liquid-based samples;
• molecular testing and strategies that improve turnaround time and cost;
• molecular pathology for understanding tumor subtyping/classification, progression, and heterogeneity.

Dr. Hans Brunnström
Guest Editor

Manuscript Submission Information

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• diagnostic method
• liquid biopsy
• lung cancer
• molecular analysis
• precision medicine
• predictive biomarker