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Insects
Special Issues
The Emerging Role of Chromatin Remodelling in Insects
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The Emerging Role of Chromatin Remodelling in Insects

A special issue of Insects (ISSN 2075-4450).

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1427

Special Issue Editor

Dr. Krishnendu Mukherjee

E-Mail Website
Guest Editor
Institute of Hygiene, Westfälische Wilhelms-Universität Münster, 48149 Munster, Germany
Interests: innate immunity; epigenetics; evolutionary biology; host-pathogen interaction; biotechnology

Special Issue Information

Dear Colleagues,

Insects can amazingly adapt to every environmental condition, forming a wide range of phenotypes by maintaining genome plasticity. Rapid alterations in gene expression impacting biochemical, physiological, metabolic, and immune responses in insects are hallmarks of their quick response to any environmental change favouring their survival and reproduction. Several studies have provided experimental evidence that these insect responses are the outcome of changes in the chromatin structure through epigenetic modifications of DNA and histone proteins. Epigenetics has gained increasing interest among entomologists involved in basic and applied research, spawning a growing body of interdisciplinary study and providing us with innovative approaches to long-standing biological concerns.

This Special Issue aims to present the current state of research in the field of chromatin dynamics in the context of infection, caste distinction, polyphenism, and metamorphosis in insects.

Dr. Krishnendu Mukherjee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Insects is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • chromatin
  • insects
  • histone modifications
  • DNA methylation
  • phenotypic plasticity
  • innate immunity
  • insect resistance
  • gene expression
  • chromatin remodelers
  • DNA repair, transcription

Published Papers (1 paper)

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Research

12 pages, 1591 KiB  
Article
Alterations in Histone Methylation States Increased Profusion of Lethal(2)-Essential-for-Life-Like (l(2)elf), Trithorax and Polycomb Genes in Apis mellifera under Heat Stress
by Ahmad A. Alghamdi and Yehya Z. Alattal
Insects 2024, 15(1), 33; https://doi.org/10.3390/insects15010033 - 05 Jan 2024
Viewed by 1109
Abstract
Histone post-translational modifications (PTMs) represent a key mechanism in the thermal adaptation of the honeybee Apis mellifera. In this study, a chromatin immunoprecipitation assay and qPCR were employed to explore the changes in the methylation states of H3K4m2, H3K4m3, H3K27m2 and H3K27m3 [...] Read more.
Histone post-translational modifications (PTMs) represent a key mechanism in the thermal adaptation of the honeybee Apis mellifera. In this study, a chromatin immunoprecipitation assay and qPCR were employed to explore the changes in the methylation states of H3K4m2, H3K4m3, H3K27m2 and H3K27m3 associated with l2efl (ID: 72474, 724405, 724488), histone methyltransferases (HMTs) ((trx) and PR-set7) and Polycomb (Pc) and (Su(z)12) genes in A. m. jemenitica (tolerant subspecies) and A. m. carnica (susceptible subspecies) in response to heat treatment (42 °C for 1 h). The results revealed significant enrichment fold changes in the methylation/demethylation of most H3K4 and H3K27 marks at all targeted genes. These changes increased the profusion of l2efl (ID: 72474, 724405, 724488), histone methyltransferases (HMTs) (trx) and Polycomb (Pc) and Su(z)12 and decreased the profusion of HMT (PR-set7) in both honeybee subspecies. The changes in the methylation enrichment folds of histone methyltransferases (HMTs) ((trx), PR-set) and Polycomb (Pc), Su(z)12 genes demonstrate the well-harmonized coordination of epigenetic gene regulation in response to heat treatment. Compared to the control, the changes in the methylation enrichment folds of H3K4m3 at Polycomb Su(z)12 were about 30× and 100× higher in treated A. m. jemenitica and A.m. carnica, respectively. Similarly, changes in the methylation/demethylation enrichment folds of HMT (trx) and Polycomb (Pc) and Su(z)12 were 2–3× higher in A. m. carnica than in A. m. jemenitica after treatment (42 °C). It is evident that post-translational chromatin modification in both honeybee subspecies can diminish heat stress impact by (I) increasing the transcriptional provision of l2efl associated with survival and (II) increasing the silencing of genes associated with general cellular activities. Full article
(This article belongs to the Special Issue The Emerging Role of Chromatin Remodelling in Insects)
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