MYC, New Insights into Its Regulation and Function
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 10 September 2024 | Viewed by 259
Special Issue Editor
2. Department of Medicine & Endocrinology, NYU Langone Medical Center, Smilow Research Building, 550 First Ave, New York, NY 10016, USA
Interests: Myc; growth; ribosomal biogenesis; autophagy; insulin/TOR signaling; lipid metabolism; neuronal degeneration; Huntington’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The MYC gene is frequently deregulated in cancer, and its overexpression is associated with the development and progression of many types of tumors. In humans, the dysregulation of c-Myc can be caused by gene amplification, chromosomal translocation, or other mechanisms that promote uncontrolled cell growth and division, contributing to the formation of tumors. While MYC is commonly studied in the context of cancer, MYC's role is critical in various physiological processes, including embryonic development, tissue regeneration, and immune responses. Using animal models, notably Drosophila, researchers have investigated the consequences of altered MYC expression or activity in vivo. Manipulating the endogenous MYC levels in specific tissues or developmental stages has effects on cell competition, a conserved mechanism that regulates tissue growth and homeostasis, which is implicated in the elimination of unfit or damaged cells. Furthermore, genetic screens using in silico and animal models will continue to identify targets of MYC, providing valuable insights into the components that control its complex regulatory network.
This Special Issue aims to provide an overview of the collective efforts made by scientists to understand Myc's role in different aspects of biology, including animal development, organ growth, and tumorigenesis.
Prof. Dr. Paola Bellosta
Guest Editor
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Keywords
- control of animal development and organ growth
- Drosophila and other animal models
- rewiring metabolic pathways
- tumor growth and oncogenesis
- transcriptional regulation and chromatin remodeling
- regulatory networks and feedback loops
