Molecular Mechanism of Hematopoiesis Disorder
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 245
Special Issue Editors
Interests: hematopoiesis; self-renew; differentiation; hematopoietic cancer; molecular pathway
Special Issue Information
Dear Colleagues,
Hematopoiesis, in brief, is the blood cell production process, which starts with the hematopoietic stem and progenitor cells (HSPCs). During fetal development, hematopoiesis occurs in multiple waves throughout the developing embryo and fetus, such as the extraembryonic yolk sac (YS), the aorta–gonad–mesonephros (AGM) region, placenta and fetal liver. Around birth, fetal liver HSCs settle in the bone marrow niche. Both fetal HSCs and adult HSCs undergo self-renew and stepwise differentiation into blood lineage cells, a process termed hematopoietic hierarchy. Hematopoiesis is a complex and multi-step process governed by many factors, such as transcription factors, epigenetic modification, extracellular cytokine, signal transduction, etc.
For this Special Issue, we welcome reviews and original articles covering the molecular mechanism of normal hematopoiesis and disorders such as leukemia, lymphoma, and myeloma. We look forward to your contributions.
Dr. Jingxin Zhang
Prof. Dr. Baobing Zhao
Guest Editors
Manuscript Submission Information
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Keywords
- hematopoiesis
- hematopoietic stem cell
- hematopoietic cancer
- signal pathway
- gene regulatory network
- omics
- erythropoiesis
