Chromosome Segregation Defects in the Origin of Genomic Instability 2023
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Cytogenomics".
Deadline for manuscript submissions: closed (20 March 2023) | Viewed by 257
Special Issue Editor
Interests: chromosome segregation; cancer; genomic instability; DNA repair; Saccharomyces cerevisiae; chemical genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cell cycle, whose purpose is to become two where there was only one, is extraordinarily complex and tightly regulated. Any error in this process could cause an unsuccessful transmission of genetic material, leading to cancer or birth defects. A key stage during the cell cycle is anaphase, where an army of proteins gradually resolve, separate, and pull the sister chromatids to the daughter cells. Anaphase is particularly concerning as a source of genomic instability, since there are no good options for the cell to correctly deal with chromosome segregation errors.
There are several genetically inherited human diseases, especially cancer-prone syndromes, that show chromosome segregation defects at the cellular level. In addition, many carcinogens and, paradoxically, clinically used antitumor agents have a direct impact on the fidelity of chromosome transmission. Amongst the most common anaphase aberrations, we find chromatin and ultrafine anaphase bridges, lagging chromosomes, the breakage–fusion–bridge cycle, and chromosome nondisjunction. The physical causes of these aberrations include the unnatural presence of under-replicated chromosomes, unresolved recombination intermediates, topological constrains, proteinaceous linkages, multicentric chromosomes, telomere fusions, syntelyc/monotelyc attachments, and polycentrosomy. At a molecular level, mutations in numerous genes cause chromosome segregation defects, including those genes involved in DNA damage and replication checkpoints, the spindle assembly checkpoint, the structural maintenance of chromosomes (SMC) complexes (condensin, cohesin, and Smc5/6), topoisomerase II, DNA repair helicases, and structure-specific endonucleases.
This is a edition 2.0. 8 excellent papers have been collected in edition 1.0. Please find more details by click the link:
Edition 1.0: https://www.mdpi.com/journal/genes/special_issues/Chromosome_Segregation_Origin
In this Special Issue, we aim to gather a collection of reviews, research articles, and concept papers about the molecular players involved in the successful segregation of chromosomes, both in mitosis and meiosis, as well as manuscripts dealing with the instability footprints found in the progeny.
Dr. Félix Machín
Guest Editor
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Keywords
- genome instability
- chromosome segregation
- mitotic catastrophe
- anaphase bridges
- cohesins
- condensins
- topoisomerases
- DNA repair
- checkpoints
- mitosis
- meiosis
- cancer
