Pharmacogenomics: Challenges and Future (Volume II)
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 10 August 2024 | Viewed by 69
Special Issue Editor
Interests: pharmacogenetics; biomarkers; cancer; medicine for drug addiction; alcoholism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the past years, the growth of pharmacogenomics (PGx) within the medical community has contributed to improving the practice of precision medicine. The genetic make-up influences the interindividual variability of drug responses in terms of dosing, drug efficacy/toxicity, hypersensitivity reactions, drug resistance, and clinical outcome. The discovery of PGx biomarkers may lead to tailored prescriptions, with a major impact on healthcare costs. Until now, FDA recommendations are provided for over 200 drugs in several therapeutic areas, especially for cancer. However, PGx implementation is still limited, and several barriers need to be overcome. For this Special Issue, contributions from both experts and beginners in the PGx field are invited. We welcome reviews and original research articles covering many aspects of PGx, from the discovery of new PGx biomarkers to methodological strategies to increase PGx knowledge and implementation, including the validation of PGx biomarkers for clinical translation. Moreover, studies on ethical, legal, and economic aspects and on the role of epigenetic and non-genetic factors are also welcome.
Dr. Mariamena Arbitrio
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- ADME genes
- regulation of interindividual variability
- polymorphic variant
- single-nucleotide polymorphism (SNP)
- rare variants and copy number variation (CNV)
- biomarkers
- pharmacokinetics (PK)/pharmacodynamics (PD)
- PGx genotyping strategies
- PGx implementation
- PGx discovery tools
- PGx validation tools
- preemptive dose modulation
