Genomic Approaches for Disease Diagnosis and Prognosis: From Clinomics to Single-Cell Sequencing and Spatial Transcriptomics
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Genetic Diagnosis".
Deadline for manuscript submissions: 15 December 2024 | Viewed by 111
Special Issue Editor
Interests: lncRNA-mediated transcriptional regulation; RNA–chromatin interactions; chromatin architecture; transcriptional and epigenetic regulation in cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last two decades, next generation sequencing (NGS) facilitated the transition of biomedical research into the post-genomic era. Today international consortia, including but not limited to The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC) and the Genotype-Tissue Expression project (gTEX), combine molecular insights (e.g., DNA sequence and structure and/or RNA or protein expression) with clinical manifestations, thereby promoting the development of novel diagnostic and prognostic biomarkers or therapeutic targets.
The same efforts highlight the extensive cellular and molecular heterogeneity that governs complex diseases such as cancer. The development of state-of the art genomic approaches, including single cell sequencing and more recently spatial transcriptomics, is already transforming cellular or spatially organized molecular operation to diagnostic and prognostic opportunity, thus paving the way towards personalized medicine.
This Special Issue welcomes articles that emphasize on the role of genomic approaches and/or methodologies in the form of bulk, single cell or spatial sequencing, as novel clinomics strategies designed to convert genomic function into diagnostic, prognostic and therapeutic action against complex human diseases.
Dr. Antonis Giakountis
Guest Editor
Manuscript Submission Information
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Keywords
- clinomics
- TCGA
- ICGC
- gTEX
- single cell sequencing
- spatial transcriptomics
- ribodiagnostics
- RNA therapeutics
- targeted therapy
- cancer
