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Diagnostics
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Low-Cost Diagnostic Devices
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Low-Cost Diagnostic Devices

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Point-of-Care Diagnostics and Devices".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 6078

Special Issue Editor

Dr. Azadeh Nilghaz

E-Mail Website
Guest Editor
Institute for Frontier Materials, Deakin University, Victoria 3217, Australia
Interests: fibre-based microfluidic devices; rapid detection; lab-on-a-chip; diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The diagnostic process involves a wide variety of tools and equipment which are not always affordable, available, and time-efficient. Microfluidic fibre-based devices could potentially construct low-cost diagnostic platforms alternative to conventional laboratory testing with the objectives of saving more lives and providing accessible healthcare to all. Intensive research has accumulated a huge number of scientific publications on the development of these devices. However, their evolution into a market-ready format without sacrificing sensitivity and specificity of the test outcome is a key requirement which is not being fully met and needs further research and development.

This Special issue aims to provide a peer-reviewed resource for the development of practical and marketable lab-on-a-chip devices for diagnostic applications and improve clinical outcomes and more effective patient management and safety. This issue is of interest to a broad audience of healthcare professionals and publishes original research, technical reports, short communications, and reviews. We welcome submissions on, but not limited to, the following topics:

  • Fibre-based microfluidic
  • Lab-on-a-chip device
  • Rapid diagnostic
  • Novel detection method
  • Non-invasive diagnostic method
  • Clinically validated biomarker
  • Infectious disease
  • Body fluid testing
  • Low-cost detection
  • Field setting
  • Sample-to-answer devices
  • Novel test readout

Dr. Azadeh Nilghaz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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9 pages, 1793 KiB  
Article
Extremely Precise Blood–Plasma Separation from Whole Blood on a Centrifugal Microfluidic Disk (Lab-on-a-Disk) Using Separator Gel
by Ali Hatami and Maryam Saadatmand
Diagnostics 2022, 12(11), 2873; https://doi.org/10.3390/diagnostics12112873 - 20 Nov 2022
Cited by 5 | Viewed by 2644
Abstract
Due to the expansion of point-of-care devices, proposing a convenient and efficient method for blood–plasma separation would help with the use of point-of-care devices. Commercial microfluidic chips are only able to separate a limited amount of plasma, and the majority of these chips [...] Read more.
Due to the expansion of point-of-care devices, proposing a convenient and efficient method for blood–plasma separation would help with the use of point-of-care devices. Commercial microfluidic chips are only able to separate a limited amount of plasma, and the majority of these chips need an active valve system, which leads to increase manufacturing cost and complexity. In this research study, we designed a centrifugal microfluidic disk with a passive valve for ultra-accurate and efficient blood–plasma separation on a large scale (2–3 mL). The disk contained a separator gel, which, after applying the centrifugal force, separated the plasma and red blood cells. The passive valve worked based on the inertial force and was able to transfer more than 90% of the separated plasma to the next chamber. The results demonstrated that the separated plasma was 99.992% pure. This study compared the efficiency of the disk containing separating gel with the common lab-on-a-disk design for plasma separation. A comparison of the results showed that although the common lab-on-a-disk design could separate almost pure plasma as the disk contained separator gel, it could only transfer 60% of plasma to the next chamber. Full article
(This article belongs to the Special Issue Low-Cost Diagnostic Devices)
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Review

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12 pages, 1675 KiB  
Review
Quantum Dot-Based Lateral Flow Immunoassay as Point-of-Care Testing for Infectious Diseases: A Narrative Review of Its Principle and Performance
by Mohamad Ahmad Najib, Kasturi Selvam, Muhammad Fazli Khalid, Mehmet Ozsoz and Ismail Aziah
Diagnostics 2022, 12(9), 2158; https://doi.org/10.3390/diagnostics12092158 - 06 Sep 2022
Cited by 7 | Viewed by 2606
Abstract
Infectious diseases are the world’s greatest killers, accounting for millions of deaths worldwide annually, especially in low-income countries. As the risk of emerging infectious diseases is increasing, it is critical to rapidly diagnose infections in the early stages and prevent further transmission. However, [...] Read more.
Infectious diseases are the world’s greatest killers, accounting for millions of deaths worldwide annually, especially in low-income countries. As the risk of emerging infectious diseases is increasing, it is critical to rapidly diagnose infections in the early stages and prevent further transmission. However, current detection strategies are time-consuming and have exhibited low sensitivity. Numerous studies revealed the advantages of point-of-care testing, such as those which are rapid, user-friendly and have high sensitivity and specificity, and can be performed at a patient’s bedside. The Lateral Flow Immunoassay (LFIA) is the most popular diagnostic assay that fulfills the POCT standards. However, conventional AuNPs-LFIAs are moderately sensitive, meaning that rapid detection remains a challenge. Here, we review quantum dot (QDs)-based LFIA for highly sensitive rapid diagnosis of infectious diseases. We briefly describe the principles of LFIA, strategies for applying QDs to enhance sensitivity, and the published performance of the QD-LFIA tested against several infectious diseases. Full article
(This article belongs to the Special Issue Low-Cost Diagnostic Devices)
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