Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Diagnosis and Management of Rectal Cancer
share announcement

Diagnosis and Management of Rectal Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 18923

Special Issue Editors

Prof. Dr. Gaetano Luglio

E-Mail Website
Guest Editor
Università degli Studi di Napoli Federico II, Naples, Italy
Interests: surgical oncology; colorectal surgery; general surgery; laparoscopic surgery; abdominal surgery; cancer surgery; minimally invasive surgery; gastrointestinal surgery; advance laparoscopic surgery; laparoscopic cholecystectomy
Prof. Dr. Giovanni Domenico De Palma

E-Mail Website
Co-Guest Editor
Department of Clinical Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, Italy
Interests: endoscopic mucosal resection; endoscopic submucosal dissection; transanal endoscopic microsurgery; endoscopy; surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As you are all aware, rectal cancer has one of the highest incidences of all the malignant neoplasms in the world. As the title suggests, this Special Issue aims to address the most popular topics in current practice.

Novel diagnostic approaches are now available, despite the fact that they are not always routinely used in clinical practice (e.g., confocal laser endomicroscopy, augmented endoscopy and indocyanine green) other than with biomarkers that might also have a role as screening tools. The role of dedicated MRI sequences is also very much debated, even in restaging after neoadjuvant chemoradiotherapy.

Particular attention will be paid to surgical techniques and the effectiveness of minimally invasive surgery, including laparoscopic, robotic and transanal surgery; in fact, despite consistent improvements, a better quality of life and reduced morbidity are always gained by both surgeons and patients.

Additionally, this Issue will shed light on the topic of locally advanced rectal cancer and its diagnostic/therapeutic features, as well as its oncological outcomes. Furthermore, we are particularly interested in highlighting the effectiveness and feasibility of predicting patients’ responses to neoadjuvant chemoradiotherapy (CRT) and their further therapeutic management. Exploring the following questions is also important; How should we view the ‘watch and wait’ approach? When should one operate? When should one not operate?

In conclusion, this Special Issue will include original contributions and review articles which focus on the above-mentioned topics, and which help to consistently improve the quality of patients’ care.

Prof. Dr. Gaetano Luglio
Prof. Dr. Giovanni Domenico De Palma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Rectal cancer
  • Neoadjuvant chemoradiotherapy
  • TaTME (transanal total mesorectal excision)
  • Laparoscopic surgery
  • Robotic surgery
  • Biomarkers
  • Confocal laser endomicroscopy
  • Watch and wait
  • Indocyanine green
  • Quality of life
  • Augmented endoscopy

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 968 KiB  
Article
Watch and Wait Approach for Rectal Cancer Following Neoadjuvant Treatment: The Experience of a High Volume Cancer Center
by Daniela Rega, Vincenza Granata, Carmela Romano, Valentina D’Angelo, Ugo Pace, Roberta Fusco, Carmela Cervone, Vincenzo Ravo, Fabiana Tatangelo, Antonio Avallone, Antonella Petrillo and Paolo Delrio
Diagnostics 2021, 11(8), 1507; https://doi.org/10.3390/diagnostics11081507 - 21 Aug 2021
Cited by 12 | Viewed by 3291
Abstract
Multimodal treatments for rectal cancer, along with significant research on predictors to response to therapy, have led to more conservative surgical strategies. We describe our experience of the rectal sparing approach in rectal cancer patients with clinical complete response (cCR) after neoadjuvant treatment. [...] Read more.
Multimodal treatments for rectal cancer, along with significant research on predictors to response to therapy, have led to more conservative surgical strategies. We describe our experience of the rectal sparing approach in rectal cancer patients with clinical complete response (cCR) after neoadjuvant treatment. We also specifically highlight our clinical and imaging criteria to select patients for the watch and wait strategy (w&w). Data came from 39 out of 670 patients treated for locally advanced rectal cancer between January 2016 until February 2020. The selection criteria were a clinical complete response after neoadjuvant chemotherapy managed with a watch and wait (w&w) strategy. A strict follow-up period was adopted in these selected patients and follow-ups were performed every three months during the first two years and every six months after that. The median follow-up time was 28 months. Six patients had a local recurrence (15.3%); all were salvageable by total mesorectal excision (TME). Five patients had a distant metastasis (12.8%). There was no local unsalvageable disease after w&w strategy. The rectal sparing approach in patients with clinical complete response after neoadjuvant treatment is the best possible treatment and is appropriate to analyze from this perspective. The watch and wait approach after neoadjuvant treatment for rectal cancer can be successfully explored after inflexible and strict patient selection. Full article
(This article belongs to the Special Issue Diagnosis and Management of Rectal Cancer)
►▼ Show Figures

Figure 1

12 pages, 831 KiB  
Article
Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?
by Richard Partl, Katarzyna Lukasiak, Bettina Stranz, Eva Hassler, Marton Magyar, Heidi Stranzl-Lawatsch and Tanja Langsenlehner
Diagnostics 2021, 11(6), 946; https://doi.org/10.3390/diagnostics11060946 - 25 May 2021
Cited by 1 | Viewed by 1392
Abstract
There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study [...] Read more.
There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study was to investigate the association between inflammation-based parameters and the sphincter-preserving surgery rate in patients with low-lying locally advanced rectal cancer (LARC). A total of 848 patients with LARC undergoing radiotherapy from 2004 to 2019 were retrospectively reviewed in order to identify patients with rectal cancer localized ≤6 cm from the anal verge, treated with neo-adjuvant radiochemotherapy (nRCT) and subsequent surgery. Univariable and multivariable analyses were used to investigate the role of pre-treatment inflammatory parameters, including the C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the prediction of sphincter preservation. A total of 363 patients met the inclusion criteria; among them, 210 patients (57.9%) underwent sphincter-preserving surgery, and in 153 patients (42.1%), an abdominoperineal rectum resection was performed. Univariable analysis showed a significant association of the pre-treatment CRP value (OR = 2.548, 95% CI: 1.584–4.097, p < 0.001) with sphincter preservation, whereas the pre-treatment NLR (OR = 1.098, 95% CI: 0.976–1.235, p = 0.120) and PLR (OR = 1.002, 95% CI: 1.000–1.005, p = 0.062) were not significantly associated with the type of surgery. In multivariable analysis, the pre-treatment CRP value (OR = 2.544; 95% CI: 1.314–4.926; p = 0.006) was identified as an independent predictive factor for sphincter-preserving surgery. The findings of the present study suggest that the pre-treatment CRP value represents an independent parameter predicting the probability of sphincter-preserving surgery in patients with low-lying LARC. Full article
(This article belongs to the Special Issue Diagnosis and Management of Rectal Cancer)
►▼ Show Figures

Figure 1

14 pages, 1037 KiB  
Article
Abilities of Pre-Treatment Inflammation Ratios as Classification or Prediction Models for Patients with Colorectal Cancer
by Andra Ciocan, Răzvan A. Ciocan, Nadim Al Hajjar, Claudia D. Gherman and Sorana D. Bolboacă
Diagnostics 2021, 11(3), 566; https://doi.org/10.3390/diagnostics11030566 - 21 Mar 2021
Cited by 4 | Viewed by 2352
Abstract
Background: Systemic inflammatory status is known as an important factor of colorectal cancer prognosis. Our study aimed to evaluate the performances of inflammation biomarker ratios as classification models of seven outcomes in patients with colorectal cancer. Methods: A retrospective cohort study was conducted [...] Read more.
Background: Systemic inflammatory status is known as an important factor of colorectal cancer prognosis. Our study aimed to evaluate the performances of inflammation biomarker ratios as classification models of seven outcomes in patients with colorectal cancer. Methods: A retrospective cohort study was conducted on subjects with colorectal cancer over five years at a single center in Transylvania, Romania. Seven derived ratios were calculated based on laboratory data: neutrophil-to-lymphocyte (NLR), derived neutrophil-to-lymphocyte (dNLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR) and albumin-to-globulin (AGR) ratios, Systemic Immune Inflammation Index (SII) and Prognostic Nutritional Index (PNI). The utility of these ratios as predictors for seven outcomes was further evaluated in multivariable regression models. Results: Our study shows that the evaluated ratios exhibit specific performances for individual outcomes, proving a fair ability as screening tools (NLR and dNLR for survival, T stage and M stage; NLR and SII for T stage; and PLR for M stage). A dNLR over 3.1 (OR = 2.48, 95% CI (1.421 to 4.331)) shows predictive value for survival. A value of NLR over 3.10 (OR = 1.389, 95% CI (1.061 to 1.817)) is positively associated with an advanced T stage, while LMR is negatively related to the T stage (OR = 0.919, 95% CI (0.867 to 0.975)). NLR over 4.25 (OR = 2.647, 95% CI (2.128 to 3.360)) is positively associated with, while PNI is negatively related (OR = 0.970, 95% CI (0.947 to 0.993)) to, the M stage. Conclusion: Each of the evaluated ratios possesses prognostic value for certain outcomes considered, but the reported models need external validation to recommend their clinical practice utilization. Full article
(This article belongs to the Special Issue Diagnosis and Management of Rectal Cancer)
►▼ Show Figures

Figure 1

12 pages, 2555 KiB  
Article
Synchronous Colorectal Cancer: Improving Accuracy of Detection and Analyzing Molecular Heterogeneity—The Main Keys for Optimal Approach
by Patricia Simu, Ioan Jung, Laura Banias, Zsolt Kovacs, Zsolt Zoltan Fulop, Tivadar Bara, Iunius Simu and Simona Gurzu
Diagnostics 2021, 11(2), 314; https://doi.org/10.3390/diagnostics11020314 - 15 Feb 2021
Cited by 3 | Viewed by 2749
Abstract
Background: In patients with synchronous colorectal cancer (SCRC), understanding the underlying molecular behavior of such cases is mandatory for designing individualized therapy. The aim of this paper is to highlight the importance of transdisciplinary evaluation of the pre- and post-operative assessment of patients [...] Read more.
Background: In patients with synchronous colorectal cancer (SCRC), understanding the underlying molecular behavior of such cases is mandatory for designing individualized therapy. The aim of this paper is to highlight the importance of transdisciplinary evaluation of the pre- and post-operative assessment of patients with SCRCs, from imaging to molecular investigations. Methods: Six patients with SCRCs presented with two carcinomas each. In addition to the microsatellite status (MSS), the epithelial mesenchymal transition was checked in each tumor using the biomarkers β-catenin and E-cadherin, same as KRAS and BRAF mutations. Results: In two of the patients, the second tumor was missed at endoscopy, but diagnosed by a subsequent computed-tomography-scan (CT-scan). From the six patients, a total of 11 adenocarcinomas (ADKs) and one squamous cell carcinoma (SCC) were analyzed. All the examined carcinomas were BRAF-wildtype microsatellite stable tumors with an epithelial histological subtype. In two of the six cases, KRAS gene status showed discordance between the two synchronous tumors, with mutations in the index tumors and wildtype status in the companion ones. Conclusions: Preoperative CT-scans can be useful for detection of synchronous tumors which may be missed by colonoscopy. Where synchronous tumors are identified, therapy should be based on the molecular profile of the indexed tumors. Full article
(This article belongs to the Special Issue Diagnosis and Management of Rectal Cancer)
►▼ Show Figures

Figure 1

Review

Jump to: Research

13 pages, 987 KiB  
Review
Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)
by Francesco Maione, Alessia Chini, Marco Milone, Nicola Gennarelli, Michele Manigrasso, Rosa Maione, Gianluca Cassese, Gianluca Pagano, Francesca Paola Tropeano, Gaetano Luglio and Giovanni Domenico De Palma
Diagnostics 2021, 11(5), 771; https://doi.org/10.3390/diagnostics11050771 - 25 Apr 2021
Cited by 25 | Viewed by 8225
Abstract
Rectal neuroendocrine tumors (NETs) are rare, with an incidence of 0.17%, but they represent 12% to 27% of all NETs and 20% of gastrointestinal NETs. Although rectal NETs are uncommon tumors, their incidence has increased over the past few years, and this is [...] Read more.
Rectal neuroendocrine tumors (NETs) are rare, with an incidence of 0.17%, but they represent 12% to 27% of all NETs and 20% of gastrointestinal NETs. Although rectal NETs are uncommon tumors, their incidence has increased over the past few years, and this is probably due to the improvement in detection rates made by advanced endoscopic procedures. The biological behavior of rectal NETs may be different: factors predicting the risk of metastases have been identified, such as size and grade of differentiation. The tendency for metastatic diffusion generally depends on the tumor size, muscular and lymphovascular infiltration, and histopathological differentiation. According to the current European Neuroendocrine Tumor Society (ENETS) guidelines, tumors that are smaller than 10 mm and well differentiated are thought to have a low risk of lymphovascular invasion, and they should be completely removed endoscopically. Rectal NETs larger than 20 mm have a higher risk of involvement of muscularis propria and high metastatic risk and are candidates for surgical resection. There is controversy over rectal NETs of intermediate size, 10–19 mm, where the metastatic risk is considered to be 10–15%: assessment of tumors endoscopically and by endoanal ultrasound should guide treatment in these cases towards endoscopic, transanal, or surgical resection. Full article
(This article belongs to the Special Issue Diagnosis and Management of Rectal Cancer)
►▼ Show Figures

Scheme 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop