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Diagnostics
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Updates on the Diagnosis and Management of Heart, Lung, and...
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Updates on the Diagnosis and Management of Heart, Lung, and Kidney Transplantation

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1055

Special Issue Editor

Dr. Natalia Buda

E-Mail Website
Guest Editor
1. Simulation Laboratory of Endoscopic and Minimally Invasive Techniques, Medical University of Gdansk, Gdansk, Poland
2. Lung Transplantation Department, Cardiac Surgery Clinic, University Clinical Center, Gdansk, Poland
Interests: heart transplantation; lung transplantation; kidney transplantation

Special Issue Information

Dear Colleagues,

In the dynamic field of organ transplantation, continuous advancements are reshaping our understanding and practices. This Special Issue is dedicated to the latest developments in heart, lung, and kidney transplantation, reflecting the interdisciplinary nature and technological innovations in this critical area of medicine.

Scope of the Special Issue:

This Special Issue aims to collate and disseminate cutting-edge research, reviews, and case studies focusing on recent innovations and challenges in the transplantation of heart, lung, and kidney organs. We invite contributions that cover a wide range of topics, including but not limited to, the following:

  1. Surgical Techniques and Innovations: Insights into novel surgical approaches, improvements in organ preservation, and transplantation techniques.
  2. Immunological Advances: Updates on immunosuppressive therapies, rejection management, and immune tolerance strategies.
  3. Mechanical Circulatory Support (MCS): Groundbreaking research and advancements in MCS devices, their integration with transplant procedures, patient selection criteria, management strategies, and outcomes.
  4. Technological and Engineering Breakthroughs: Contributions detailing technological advancements such as organ bioengineering, 3D printing in transplantation, and innovations in organ transport systems.

Submission Guidelines:

We encourage submissions of original research articles, comprehensive review papers, and insightful case reports that contribute to this field's breadth and depth of understanding. Submissions should ideally focus on novel methodologies, clinical efficacy, comparative studies, and technological innovations related to heart, lung, and kidney transplantation.

Why Contribute to This Special Issue?

Your contributions will play a crucial role in expanding the scope of knowledge in transplantation medicine, providing a platform for sharing breakthroughs and facilitating collaborations among clinicians and researchers. This Special Issue will serve as a vital resource for the medical community, offering new perspectives and guiding future research and clinical practice.

We eagerly anticipate your valuable contributions and look forward to a collection of articles that reflect the dynamic and evolving landscape of heart, lung, and kidney transplantation.

Dr. Natalia Buda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart transplantation
  • lung transplantation
  • kidney transplantation

Published Papers (2 papers)

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Research

11 pages, 1188 KiB  
Article
Advanced Respiratory Failure Requiring Tracheostomy—A Marker of Unfavourable Prognosis after Heart Transplantation
by Marta Załęska-Kocięcka, Marco Morosin, Jonathan Dutton, Rita Fernandez Garda, Katarzyna Piotrowska, Nicholas Lees, Tuan-Chen Aw, Diana Garcia Saez and Ana Hurtado Doce
Diagnostics 2024, 14(8), 851; https://doi.org/10.3390/diagnostics14080851 - 20 Apr 2024
Viewed by 370
Abstract
Advanced respiratory failure with tracheostomy requirement is common in heart recipients. The aim of the study is to assess the tracheostomy rate after orthotopic heart transplantation and identify the subgroups of patients with the highest need for tracheostomy and these groups’ association with [...] Read more.
Advanced respiratory failure with tracheostomy requirement is common in heart recipients. The aim of the study is to assess the tracheostomy rate after orthotopic heart transplantation and identify the subgroups of patients with the highest need for tracheostomy and these groups’ association with mortality at a single centre through a retrospective analysis of 140 consecutive patients transplanted between December 2012 and July 2018. As many as 28.6% heart recipients suffered from advanced respiratory failure with a need for tracheostomy that was performed after a median time of 11.5 days post-transplant. Tracheostomy was associated with a history of stroke (OR 3.4; 95% CI) 1.32–8.86; p = 0.012), previous sternotomy (OR 2.5; 95% CI 1.18–5.32; p = 0.017), longer cardiopulmonary bypass time (OR 1.01; 95% CI 1.00–1.01; p = 0.007) as well as primary graft failure (OR 6.79; 95% CI2.93–15.71; p < 0.001), need of renal replacement therapy (OR 19.2; 95% 2.53–146; p = 0.004) and daily mean SOFA score up to 72 h (OR 1.50; 95% 1.23–1.71; p < 0.01). One-year mortality was significantly higher in patients requiring a tracheostomy vs. those not requiring one during their hospital stay (50% vs. 16%, p < 0.001). The need for tracheostomy in heart transplant recipients was 30% in our study. Advanced respiratory failure was associated with over 3-fold greater 1-year mortality. Thus, tracheostomy placement may be regarded as a marker of unfavourable prognosis. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Management of Heart, Lung, and Kidney Transplantation)
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16 pages, 557 KiB  
Article
Deceased Kidney Donor Biomarkers: Relationship between Delayed Kidney Function and Graft Function Three Years after Transplantation
by Rima Maslauskiene, Ruta Vaiciuniene, Peteris Tretjakovs, Gita Gersone, Aurelija Radzeviciene, Andrejus Bura, Edgaras Stankevicius and Inga Arune Bumblyte
Diagnostics 2024, 14(7), 717; https://doi.org/10.3390/diagnostics14070717 - 28 Mar 2024
Viewed by 480
Abstract
With an increasing number of marginal donors, additional methods for the evaluation of cadaveric kidney quality are required. This study aimed to evaluate pretransplant deceased donor serum (s) and urine (u) biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18, and [...] Read more.
With an increasing number of marginal donors, additional methods for the evaluation of cadaveric kidney quality are required. This study aimed to evaluate pretransplant deceased donor serum (s) and urine (u) biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18, and C-X-C motif chemokine 10 (CXCL10) for predicting early and late graft function. In total, 43 deceased kidney donors and 76 corresponding recipients were enrolled. Delayed graft function (DGF) occurred in 27.6% of cases. sIL-18, sKIM-1, uNGAL, and uKIM-1 were predictors of DGF. A model incorporating sIL-18, uKIM-1, and clinical factors was developed to predict DGF (AUROC 0.863). Univariate analysis showed a negative association between uKIM and graft eGFR at 6, 12, 24, and 36 months, but this was not confirmed in the multivariate analysis. In conclusion, we report a superior performance of donor biomarkers for predicting DGF and later graft function over serum creatinine. Higher levels of donor sIL-18 and uKIM in conjunction with expanded-criteria donors and longer cold ischemia times predicted DGF. With no renal tubular damage in zero-time donor biopsies, higher pretransplant urine and serum NGAL levels were associated with better allograft function one year after transplantation, and sNGAL with graft function three years after transplantation. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Management of Heart, Lung, and Kidney Transplantation)
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