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Optical Coherence Tomography Imaging in Retinopathy: New Advances and Future...
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Optical Coherence Tomography Imaging in Retinopathy: New Advances and Future Trends

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3052

Special Issue Editor

Dr. Slawomir Teper

E-Mail Website
Guest Editor
Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
Interests: retinal diseases; uveitis; ophthalmic genetics; imaging of the posterior segment of the eye
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

OCT has changed ophthalmology, with advances in OCT imaging expanding the diagnostic possibilities of posterior segment diseases. The purpose of this Special Issue is to look into the future, but also to observe current trends in the field of OCT technology in retinal diseases. Research papers, literature reviews, meta-analyses, and case reports can be submitted.

This Special Issue will explore but is not restricted to the following topics:

  1. OCT in retinal diseases—new applications and methods of data analysis;
  2. OCTA in retinal diseases—advances in imaging and analysis of the retinal vascular network;
  3. Comparison of methods and devices used in OCT imaging;
  4. OCT algorithms—retinal segmentation, automated disease classification, imaging quality assessment, deep learning.

Dr. Sławomir Teper
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography
  • optical coherence tomography angiography
  • retina
  • retinopathy
  • retinal degeneration

Published Papers (3 papers)

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Research

13 pages, 1492 KiB  
Article
Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network
by Adam Sendecki, Daniel Ledwoń, Aleksandra Tuszy, Julia Nycz, Anna Wąsowska, Anna Boguszewska-Chachulska, Adam Wylęgała, Andrzej W. Mitas, Edward Wylęgała and Sławomir Teper
Diagnostics 2024, 14(7), 770; https://doi.org/10.3390/diagnostics14070770 - 05 Apr 2024
Viewed by 497
Abstract
Background: Age-related macular degeneration (AMD) is a multifactorial disease encompassing a complex interaction between aging, environmental risk factors, and genetic susceptibility. The study aimed to determine whether there is a relationship between the polygenic risk score (PRS) in patients with AMD and the [...] Read more.
Background: Age-related macular degeneration (AMD) is a multifactorial disease encompassing a complex interaction between aging, environmental risk factors, and genetic susceptibility. The study aimed to determine whether there is a relationship between the polygenic risk score (PRS) in patients with AMD and the characteristics of the retinal vascular network visualized by optical coherence tomography angiography (OCTA). Methods: 235 patients with AMD and 97 healthy controls were included. We used data from a previous AMD PRS study with the same group. The vascular features from different retina layers were compared between the control group and the patients with AMD. The association between features and PRS was then analyzed using univariate and multivariate approaches. Results: Significant differences between the control group and AMD patients were found in the vessel diameter distribution (variance: p = 0.0193, skewness: p = 0.0457) and fractal dimension distribution (mean: p = 0.0024, variance: p = 0.0123). Both univariate and multivariate analyses showed no direct and significant association between the characteristics of the vascular network and AMD PRS. Conclusions: The vascular features of the retina do not constitute a biomarker of the risk of AMD. We have not identified a genotype–phenotype relationship, and the expression of AMD-related genes is perhaps not associated with the characteristics of the retinal vascular network. Full article
(This article belongs to the Special Issue Optical Coherence Tomography Imaging in Retinopathy: New Advances and Future Trends)
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13 pages, 2286 KiB  
Article
An Optical Coherence Tomography-Based Measure as an Independent Estimate of Retinal Function in Retinitis Pigmentosa
by Manuel Paez-Escamilla, Michelle L. Alabek, Oliver Beale, Colin J. Prensky, Raphael Lejoyeux, Thomas R. Friberg, Jose-Alain Sahel and Boris Rosin
Diagnostics 2023, 13(23), 3521; https://doi.org/10.3390/diagnostics13233521 - 24 Nov 2023
Viewed by 969
Abstract
Background: With the clinical advances in the field of gene therapy, the development of objective measures of visual function of patients with inherited retinal dystrophies (IRDs) is of utmost importance. Here, we propose one such measure. Methods: We retrospectively analyzed data from a [...] Read more.
Background: With the clinical advances in the field of gene therapy, the development of objective measures of visual function of patients with inherited retinal dystrophies (IRDs) is of utmost importance. Here, we propose one such measure. Methods: We retrospectively analyzed data from a cohort of 194 eyes of 97 genetically diagnosed patients with retinitis pigmentosa (RP), the most common IRD, followed at the UPMC Vision Institute. The analyzed data included the reflectivity ratio (RR) of the retinal nerve fiber layer (RNFL) to that of the entire retina, visual acuity (VA) and the thickness of the retinal outer nuclear layer (ONL) and the RNFL. Results: There was a strong positive correlation between the RR and VA. Both VA and the RR were negatively correlated with disease duration; VA, but not the RR, was negatively correlated with age. The RR correlated with the ONL but not with the RNFL thickness or the intraocular pressure. Age, RR, disease duration and ONL thickness were found to be independent predictors of VA by multivariate analysis. Conclusion: The OCT RR could serve as an independent predictor of visual acuity, and by extension of retinal function, in genetically diagnosed RP patients. Such objective measures can be of great value in patient selection for therapeutic trials. Full article
(This article belongs to the Special Issue Optical Coherence Tomography Imaging in Retinopathy: New Advances and Future Trends)
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12 pages, 4882 KiB  
Article
Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma
by Gabriella De Salvo, Mohamed Oshallah, Anastasios E. Sepetis, Ramez Borbara, Giovanni William Oliverio, Alessandro Meduri, Rino Frisina and Aby Jacob
Diagnostics 2023, 13(22), 3428; https://doi.org/10.3390/diagnostics13223428 - 10 Nov 2023
Viewed by 1137
Abstract
Purpose: to assess the tomographic retinal layers’ thickness in eyes affected by branch retinal artery occlusion (BRAO) and to compare it to those of patients affected by primary open angle glaucoma (POAG). Methods: retrospective review of 27 patients; 16 with BRAO (16 eyes) [...] Read more.
Purpose: to assess the tomographic retinal layers’ thickness in eyes affected by branch retinal artery occlusion (BRAO) and to compare it to those of patients affected by primary open angle glaucoma (POAG). Methods: retrospective review of 27 patients; 16 with BRAO (16 eyes) and 11 with POAG (20 eyes) were identified among those who received SD-OCT scans, including analysis of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), neuroretinal rim (NRR), circumpapillary RNFL at 3.5 mm and hemisphere asymmetry (HA). Results: the total IPL and INL thinning difference between the two groups was statistically significant (p = 0.0067 and p < 0.0001, respectively). The HA difference for the total macular thinning, mRNFL, GCL, IPL and INL (p < 0.0001) was also statistically significant. The analysis of the average total retinal thinning, total mRNFL and GCL thinning showed no statistically significant difference between the two groups. Conclusions: unilateral inner retinal thinning may represent a sign of temporal BRAO, particularly for INL thinning and HA difference over 17µm in total retinal layer thinning. This information is particularly useful in the diagnosis of previous, undiagnosed BRAO and may help prevent further retinal arterial occlusion and possible cerebrovascular incidents. Full article
(This article belongs to the Special Issue Optical Coherence Tomography Imaging in Retinopathy: New Advances and Future Trends)
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