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Dear Colleagues,

We are pleased to invite you to submit a manuscript to this Special Issue of Diagnostics entitled “Nuclear Medicine Imaging and Therapy in Breast Cancer”. Breast cancer is the most prevalent cancer among women worldwide. Nuclear medicine imaging plays a key role in many clinical settings of breast cancer, with numerous radiotracers available or under investigation. Such advancements in diagnostic imaging and therapy, together with the introduction of artificial intelligence technology in clinical practice, will accelerate the advent of truly personalized medicine.

In this Special Issue of Diagnostics, we plan to address the complexity of molecular imaging and theranostics in breast cancer. We prioritize high-quality original studies, encourage the submission of multidisciplinary works, and welcome well-designed meta-analyses and reviews.

Dr. Luca Urso
Dr. Priscilla Guglielmo
Dr. Laura Evangelista
Guest Editors

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Keywords

breast cancer
18F-FDG PET/CT or PET/MRI
18F-FES PET/CT
theranostics
beta-based therapy
alpha-based therapy
radiomics and artificial intelligence
alternative radiotracers
68Ga-FAPI or 18F-FAPI PET/CT

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23 pages, 5274 KiB

Open AccessSystematic Review

Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis

by Hortência H. J. Ferreira, Carla Daruich de Souza, Lorena Pozzo, Martha S. Ribeiro and Maria Elisa C. M. Rostelato

Diagnostics 2024, 14(4), 441; https://doi.org/10.3390/diagnostics14040441 - 17 Feb 2024

Viewed by 723

Abstract

Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies. Full article

(This article belongs to the Special Issue Nuclear Medicine Imaging and Therapy in Breast Cancer)

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