The Immunological Basis of Genesis of Gastrointestinal Cancer and Its Diagnostic and Therapeutic Implications

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 5371

Special Issue Editors


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Guest Editor
1. University Hospital of Coventry and Warwickshire, Coventry CV2 2DX, UK
2. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
3. Health, Biological & Experimental Sciences, University of Coventry, Coventry CV1 5FB, UK
4. School of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
Interests: colon cancer biomarker; volatile organic compounds; bile acid pathophysiology and artificial intelligence
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Guest Editor
Department of Surgery and Cancer, Imperial College London, London W12 OHS, UK
Interests: general surgery; hepatobiliary & pancreatic surgery; kidney and liver transplant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

An immunopathological understanding behind the genesis of various gastrointestinal cancers, including liver, colorectal, and pancreatic cancer, is needed. The introduction of immunomodulatory changes behind immune evasion has a substantial effect on the progression of cancer, and has brought significant changes in the diagnostic categorization and therapeutic approaches. The molecular characterization of the immune evasion mechanism has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcomes.

The rapid advancement and expansion in the knowledge of immunomodulatory changes and the reinstatement of immunity has evolved in the diagnosis and management of these cancers; hence, this Special Issue of Diagnostics intends to add to the current knowledge with key articles that critically outline the diagnosis and therapeutic challenges related to gastrointestinal cancers, notably liver, pancreatic, and colorectal. Furthermore, it will also accept articles addressing impact of Covid-19 on patients receiving immunotherapy or those who have had organ transplants.

Prof. Dr. Ramesh P. Arasaradnam
Dr. Kumar Jayant
Guest Editors

Manuscript Submission Information

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Keywords

  • Hepatocellular carcinoma
  • Cholangiocarcinoma
  • Pancreatic carcinoma
  • Neuroendocrine tumour of pancreas
  • Colorectal carcinoma
  • Colorectal liver metastasis
  • Immunomodulation
  • Checkpoint inhibitors

Published Papers (1 paper)

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Review

17 pages, 3066 KiB  
Review
Recent Advances: The Imbalance of Immune Cells and Cytokines in the Pathogenesis of Hepatocellular Carcinoma
by Kumar Jayant, Nagy Habib, Kai W. Huang, Jane Warwick and Ramesh Arasaradnam
Diagnostics 2020, 10(5), 338; https://doi.org/10.3390/diagnostics10050338 - 25 May 2020
Cited by 17 | Viewed by 4937
Abstract
Recent advancement in the immunological understanding of genesis of hepatocellular carcinoma (HCC) has implicated a decline in anti-tumour immunity on the background of chronic inflammatory state of liver parenchyma. The development of HCC involves a network of immunological activity in the tumour microenvironment [...] Read more.
Recent advancement in the immunological understanding of genesis of hepatocellular carcinoma (HCC) has implicated a decline in anti-tumour immunity on the background of chronic inflammatory state of liver parenchyma. The development of HCC involves a network of immunological activity in the tumour microenvironment involving continuous interaction between tumour and stromal cells. The reduction in anti-tumour immunity is secondary to changes in various immune cells and cytokines, and the tumour microenvironment plays a critical role in modulating the process of liver fibrosis, hepatocarcinogenesis, epithelial-mesenchymal transition (EMT), tumor invasion and metastasis. Thus, it is considered as one of primary factor behind the despicable tumour behavior and observed poor survival; along with increased risk of recurrence following treatment in HCC. The primary intent of the present review is to facilitate the understanding of the complex network of immunological interactions of various immune cells, cytokines and tumour cells associated with the development and progression of HCC. Full article
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