Advances in the Diagnosis and Management of Rheumatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 4138

Special Issue Editor


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Guest Editor
Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Interests: rheumatology; rheumatic diseases; rheumatoid arthritis

Special Issue Information

Dear Colleagues, 

Systemic autoimmune diseases are a group of heterogeneous diseases driven by autoimmune pathogenesis. The treatment of autoimmune diseases with a “treat to target” strategy was established in 2009. The principle of treat-to-target involves several steps, including target identification, initiation of medication and achievement of disease activity score. All of these require accurate and effective biomarkers. For rheumatoid arthritis, rheumatoid factor (RF) and anti-CCP antibody aid in accurate diagnosis. ESR and CRP can evaluate disease activity. Recently, precise therapy referred to as personalized medicine has been a hot topic in the field. Even though we have many powerful biologics or tsDMARDs for the management of autoimmune diseases, we are still unable to accurately predict the outcomes of these medications.

Therefore, research on advanced biomarkers for predicting the efficacy of targeted therapy is most important. Hence, all research regarding advances in biomarkers of the efficacy of targeted therapies are welcome in this Special Issue. We warmly invite you and your colleagues to submit all types of articles—original research articles, comprehensive and critical reviews, and even letters—given the expansive interest of this area.

Dr. Wennan Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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13 pages, 1637 KiB  
Article
Genotype Triad for HOTAIR rs10783618, LINC-ROR rs1942347, and MALAT1 rs3200401 as Molecular Markers in Systemic Lupus Erythematous
by Nesreen M. Ismail, Eman A. Toraih, Amany I. Almars, Essam Al Ageeli, Manal S. Fawzy and Shymaa Ahmed Maher
Diagnostics 2022, 12(5), 1197; https://doi.org/10.3390/diagnostics12051197 - 11 May 2022
Cited by 4 | Viewed by 1725
Abstract
Accumulating evidence supports the implication of long non-coding RNAs (lncRNAs) in autoimmune diseases, including systemic lupus erythematosus (SLE). LncRNA variants could impact the development and/or outcome of the disease with variable diagnostic/prognostic utility in the clinic. We aimed to explore the contribution of [...] Read more.
Accumulating evidence supports the implication of long non-coding RNAs (lncRNAs) in autoimmune diseases, including systemic lupus erythematosus (SLE). LncRNA variants could impact the development and/or outcome of the disease with variable diagnostic/prognostic utility in the clinic. We aimed to explore the contribution of HOTAIR (rs10783618), LINC-ROR (rs1942347), and MALAT1 (rs3200401) variants to SLE susceptibility and/or severity in 163 SLE patients and age-/sex-matched controls using real-time TaqMan allelic discrimination PCR. HOTAIR rs10783618*C/C was associated with a 77% increased risk of SLE (OR = 1.77, 95%CI = 1.09–2.87, p = 0.020) under the recessive model. Similarly, MALAT1 rs3200401*T/T carriers were three times more likely to develop SLE (OR = 2.89, 95%CI = 1.42–5.90) under the recessive model. While the rs3200401*T/C genotype was associated with a 49–57% decreased risk of SLE under codominant (OR = 0.51, 95%CI = 0.31–0.82, p < 0.001) and over-dominant (OR = 0.43, 95%CI = 0.27–0.68, p < 0.001) models. LINC-ROR rs1942347*A/A patients were more likely to have a positive family history of SLE. At the same time, HOTAIR rs10783618*C/C was associated with a higher frequency of arthritis (p = 0.001) and the presence of oral ulcers (p = 0.002), while patients carrying rs10783618*T/T genotype were more likely to develop hair loss (p < 0.001), weight loss (p = 0.001), and neurological symptoms (p = 0.003). In conclusion, the studied lncRNAs, HOTAIR, and MALAT1 gene polymorphisms confer susceptibility for SLE, providing a potential theoretical basis for their clinical translation in SLE disease. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Rheumatic Diseases)
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Review

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11 pages, 544 KiB  
Review
Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms
by Lai-San Wong and Yu-Ta Yen
Diagnostics 2022, 12(7), 1772; https://doi.org/10.3390/diagnostics12071772 - 21 Jul 2022
Cited by 4 | Viewed by 2046
Abstract
Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their [...] Read more.
Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their quality of life. However, it is rarely recognized both by patients and physicians. Meanwhile, pruritus is not only a symptom but is also related to the disease severity of some ACTDs. The pathophysiology of ACTD related pruritus is ambiguous. This review summarizes the features and possible mechanisms of ACTD-related pruritus, which might lead to proper diagnosis and treatment. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Rheumatic Diseases)
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