Circulating Tumor Cells Heterogeneity and Precision Oncology “How Can You Govern a Country Which Has 246 Varieties of Cheese?” ― Charles DE Gaulle
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (31 December 2020)
Special Issue Editors
Interests: liquid biospy-driven clinical trials; cancer heterogeneity; clonal evolution; precision oncology; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: circulating tumor cells; circulating tumor DNA; liquid biopsy; liquid biopsy devices; in vitro models; tumor biology; drug resistance; molecular oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Cancer is as an invasive species, which is defined as any kind of living organism that is not native to an ecosystem, reproduces quickly, and spreads aggressively, with the potential to cause harm. In order to efficiently colonize a wide range of different microenvironments, cancer cells maintain a high degree of cellular heterogeneity. Such a plastic adaptation to different microenvironments, which leads to the existence of different ecological niches occupied by phenotypically and genetically distinct cancer cell species, plays a crucial role in regulating disease progression and therapeutic response. When cancer cells enter blood (circulating tumor cells, CTCs) they get in touch with the selective pressure of microenvironmental factors that are totally novel for cells arising from a solid tumor mass, leading to the generation of heterogeneous CTCs subpopulations, each with specific genomic features.
This Special Issue aims to deepen the knowledge of the genomic and transcriptional heterogeneity of the CTC compartment, and its significance for clinical decision making. We welcome submissions that will contribute to understanding how the blood microenvironment might shape the CTCs genome and how the maintenance of heterogeneity at a CTC level might affect precision medicine in oncology.
This is the conjunct Special Issue both in Cancers and Diagnostics. Authors are free to choose the journal they would like to submit to based on their submission topic.
Prof. Dr. Paola Gazzaniga
Dr. Chiara Nicolazzo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Circulating tumor cells
- Microenvironment
- Heterogeneity
- Precision oncology
