Adaptation Strategies of Circulating Tumor Cells
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 193
Special Issue Editors
Interests: liquid biospy-driven clinical trials; cancer heterogeneity; clonal evolution; precision oncology; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: circulating tumor cells; circulating tumor DNA; liquid biopsy; liquid biopsy devices; in vitro models; tumor biology; drug resistance; molecular oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Given the success of the first edition of the Special Issue “Circulating Tumor Cells’ Heterogeneity and Precision Oncology”, published in Cancers (https://www.mdpi.com/journal/cancers/special_issues/CTCHP_oncology), we wish to continue the exploration of this topic.
Cancer is an invasive species, which starts as a native population within a tissue and then colonizes distant environments. While spreading, cancer cells need to continuously adapt to changing environments to construct a self-sustainable tumor ecosystem. One of the most significant adaptations takes place when cancer cells suddenly find themselves in the blood, becoming circulating tumor cells (CTCs). In the new blood microenvironment, CTCs become familiar with the selective pressure of specific factors that are totally novel for cells arising from a solid tumor mass, leading to the generation of heterogeneous CTC subpopulations, each with specific genomic features.
This Special Issue aims to deepen our understanding of the adaptation mechanisms of CTCs, particularly referring to the selective pressure imposed by anticancer drugs. We welcome submissions that contribute to understanding how the blood microenvironment might shape the CTC genome and how the maintenance of heterogeneity at the CTC level might impact on precision medicine in oncology.
Prof. Dr. Paola Gazzaniga
Dr. Chiara Nicolazzo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- circulating tumor cells
- microenvironment
- genome
- heterogeneity
- precision oncology
