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Diagnostics
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Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases
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Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 4046

Special Issue Editor

Prof. Dr. Surinder S. Rana

E-Mail Website
Guest Editor
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
Interests: acute pancreatitis; chronic pancreatitis; endosongraphy

Special Issue Information

Dear Colleagues,

We have witnessed the fascinating journey of both diagnostic and interventional endoscopic ultrasound (EUS) over last three decades, which has revolutionized the management of various gastrointestinal diseases. The most significant impact of this development has been on the diagnosis and management of various pancreatic diseases. EUS provides high-resolution images of the pancreas that help in the diagnosis of early chronic pancreatitis, as well as small pancreatic tumors. EUS is considered as the investigation of choice for the diagnosis, as well as the treatment, of pancreatitis and its complications. The development of newer EUS-guided FNB needles that can sample intact tissue cores with preserved architecture has improved our ability to diagnose various pancreatic diseases accurately. Development of enhanced EUS imaging techniques, such as elastography, harmonic EUS, and CEUS, has further expanded the role of EUS in various pancreatic diseases.

I am pleased to inform you that Diagnostics is planning to publish a Special Issue on the “Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases” and has given me the responsibility to guest edit this Special Issue on a topic aptly relevant in current times. Considering your expertise in the field, it is my privilege to invite you to contribute an article on this topic.

I look forward to your contribution.

Prof. Dr. Surinder S. Rana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute pancreatitis
  • chronic pancreatitis
  • endosonography
  • pancreatic cancer
  • autoimmune pancreatitis
  • contrast ultrasound
  • elastography

Published Papers (3 papers)

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Review

12 pages, 3124 KiB  
Review
The Role of Endoscopic Ultrasound in Early Chronic Pancreatitis
by Jimil Shah, Abhirup Chatterjee and Truptesh H. Kothari
Diagnostics 2024, 14(3), 298; https://doi.org/10.3390/diagnostics14030298 - 30 Jan 2024
Viewed by 912
Abstract
Chronic pancreatitis (CP) is an irreversible and progressive inflammation of the pancreas that can involve both pancreatic parenchyma and the pancreatic duct. CP results in morphological changes in the gland in the form of fibrosis and calcification along with functional impairment in the [...] Read more.
Chronic pancreatitis (CP) is an irreversible and progressive inflammation of the pancreas that can involve both pancreatic parenchyma and the pancreatic duct. CP results in morphological changes in the gland in the form of fibrosis and calcification along with functional impairment in the form of exocrine and endocrine insufficiency. Studies on the natural history of CP reveal the irreversibility of the condition and the resultant plethora of complications, of which pancreatic adenocarcinoma is the most dreaded one. In Japanese population-based studies by Otsuki and Fuzino et al., CP was clearly shown to reduce lifespan among males and females by 10.5 years and 16 years, respectively. This dismal prognosis is superadded to significant morbidity due to pain and poor quality of life, creating a significant burden on health and health-related infrastructure. These factors have led researchers to conceptualize early CP, which, theoretically, is a reversible stage in the disease spectrum characterised by ongoing pancreatic injury with the presence of clinical symptoms and the absence of classical imaging features of CP. Subsequently, the disease is thought to progress through a compensated stage, a transitional stage, and to culminate in a decompensated stage, with florid evidence of the functional impairment of the gland. In this focused review, we will discuss the definition and concept of early CP, the risk factors and natural history of the development of CP, and the role of various modalities of EUS in the timely diagnosis of early CP. Full article
(This article belongs to the Special Issue Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases)
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30 pages, 1628 KiB  
Review
Role of Endoscopic Ultrasound in Diagnosis of Pancreatic Ductal Adenocarcinoma
by Abhirup Chatterjee and Jimil Shah
Diagnostics 2024, 14(1), 78; https://doi.org/10.3390/diagnostics14010078 - 28 Dec 2023
Viewed by 1073
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the most common (90%) type of solid pancreatic neoplasm. Due to its late presentation and poor survival rate, early diagnosis and timely treatment is of utmost importance for better clinical outcomes. Endoscopic ultrasound provides high-resolution images of the [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) is the most common (90%) type of solid pancreatic neoplasm. Due to its late presentation and poor survival rate, early diagnosis and timely treatment is of utmost importance for better clinical outcomes. Endoscopic ultrasound provides high-resolution images of the pancreas and has excellent sensitivity in the diagnosis of even small (<2 cm) pancreatic lesions. Apart from imaging, it also has an advantage of tissue acquisition (EUS fine-needle aspiration, FNA; or fine-needle biopsy, FNB) for definitive diagnoses. EUS-guided tissue acquisition plays a crucial role in genomic and molecular studies, which in today’s era of personalized medicine, are likely to become important components of PDAC management. With the use of better needle designs and technical advancements, EUS has now become an indispensable tool in the management of PDAC. Lastly, artificial intelligence for the detection of pancreatic lesions and newer automated needles for tissue acquisition will obviate observer dependency in the near future, resulting in the wider dissemination and adoption of this technology for improved outcomes in patients with PDAC. Full article
(This article belongs to the Special Issue Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases)
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12 pages, 1750 KiB  
Review
Endoscopic Ultrasound in Pancreatic Duct Anomalies
by Abhirup Chatterjee and Surinder Singh Rana
Diagnostics 2023, 13(19), 3129; https://doi.org/10.3390/diagnostics13193129 - 05 Oct 2023
Cited by 1 | Viewed by 1420
Abstract
Embryological development of the pancreas is a complex phenomenon and, therefore, it can have multiple developmental aberrations. Fortunately, the majority of these pancreatic ductal anomalies are asymptomatic with no clinical relevance and are incidentally detected during diagnostic cross-sectional imaging or endoscopic retrograde cholangiopancreatography [...] Read more.
Embryological development of the pancreas is a complex phenomenon and, therefore, it can have multiple developmental aberrations. Fortunately, the majority of these pancreatic ductal anomalies are asymptomatic with no clinical relevance and are incidentally detected during diagnostic cross-sectional imaging or endoscopic retrograde cholangiopancreatography (ERCP) or autopsy. Occasionally, pancreatic duct anomalies can result in symptoms like abdominal pain or recurrent pancreatitis. Also, an accurate pre-operative diagnosis of ductal anomalies can prevent inadvertent duct injury during surgery. Conventionally, ERCP had been used for an accurate diagnosis of pancreatic duct anomalies. However, because it is invasive and associated with a risk of pancreatitis, it has been replaced with magnetic resonance cholangiopancreatography (MRCP). MRCP has demonstrated high sensitivity and specificity for the diagnosis of ductal anomalies, which can be further improved with the use of secretin-enhanced MRCP. Endoscopic ultrasound (EUS) is a new diagnostic and interventional tool in the armamentarium of endoscopists and has demonstrated promising results in the detection of pancreatic duct variations and anomalies. Along with the visualization of the course and configuration of the pancreatic duct, EUS can also visualize changes in the pancreatic parenchyma, thereby helping with an early diagnosis of any co-existent pancreatic disease. Absence of the stack sign and crossed duct sign are important EUS features to diagnose pancreas divisum. EUS can also help with the diagnosis of other congenital ductal anomalies like annular pancreas, ansa pancreatica, and anomalous pancreaticobiliary union, although the published experience is limited. Full article
(This article belongs to the Special Issue Diagnostic Value of Endoscopic Ultrasound for Pancreatic Diseases)
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