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Diagnostics
Special Issues
Hybrid/Multimodality Cardiovascular Imaging in Large Vessel Vasculitis—2nd Edition
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Hybrid/Multimodality Cardiovascular Imaging in Large Vessel Vasculitis—2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 924

Special Issue Editors

Prof. Dr. Riemer H.J.A. Slart

E-Mail Website
Guest Editor
Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: cardiovascular diseases; PET/CT; SPECT/CT; (hybrid) imaging; multimodality imaging
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lars C. Gormsen

E-Mail Website
Guest Editor
Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, DK 8200 Aarhus, Denmark
Interests: PET; nuclear cardiology; inflammatory diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Large-vessel vasculitis (LVV) is the most common form of primary vasculitis comprising giant cell arteritis (GCA), Takayasu arteritis (TAK) and aortitis. The fields of GCA and LVV have rapidly expanded. Ultrasound-guided fast-track strategies have led to a reduction of irreversible vision loss cases, and the concept of imaging confirmed large-vessel (LV-)GCA with or without a cranial disease has been added to the disease definition. Based on these considerations, the importance of multimodality imaging including ultrasound, MRI, CT and [18F]-fluorodeoxyglucose positron emission tomography (PET)/CT has steadily increased. These techniques enable the assessment of cranial and extracranial arteries and the aorta and are less invasive, more sensitive and more quickly available than temporal artery biopsy (TAB) and conventional angiography are, which have been the sole diagnostic standards for GCA and TAK, respectively, for decades. To monitor LVV activity during and after treatment, related biomarker measurements would be helpful. However, specific serum biomarkers are lacking. Multimodality imaging can play a central role in this.

This Special Issue aims to present the role of non-invasive imaging modalities in the diagnosis and imaged-based therapeutic management of large-vessel vasculitis, with a particular attention not only to the standard of care, but also for relevant developments in the near future. We encourage authors to submit both preclinical and clinical studies in the field. Clinical studies may include systematic reviews/meta-analysis, retrospective studies and prospective studies emphasizing the role and need of imaging techniques in primary diagnosis, treatment response and disease relapse.

Prof. Dr. Riemer H.J.A. Slart
Prof. Dr. Lars C. Gormsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • large-vessel vasculitis
  • diagnosis
  • therapy response
  • multimodality imaging
  • PET/CT
  • SPECT/CT
  • CT
  • MRI
  • ultrasound

Published Papers (1 paper)

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Research

11 pages, 2247 KiB  
Article
Comparing Diagnostic Performance of Short and Long [18F]FDG-PET Acquisition Times in Giant Cell Arteritis
by Pieter H. Nienhuis, Marieke van Nieuwland, Gijs D. van Praagh, Karolina Markusiewicz, Edgar M. Colin, Kornelis S. M. van der Geest, Nils Wagenaar, Elisabeth Brouwer, Celina Alves and Riemer H. J. A. Slart
Diagnostics 2024, 14(1), 62; https://doi.org/10.3390/diagnostics14010062 - 27 Dec 2023
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Abstract
(1) Background: In giant cell arteritis (GCA), the assessment of cranial arteries using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) combined with low-dose computed tomography (CT) may be challenging due to low image quality. This study aimed to investigate the [...] Read more.
(1) Background: In giant cell arteritis (GCA), the assessment of cranial arteries using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) combined with low-dose computed tomography (CT) may be challenging due to low image quality. This study aimed to investigate the effect of prolonged acquisition time on the diagnostic performance of [18F]FDG PET/CT in GCA. (2) Methods: Patients with suspected GCA underwent [18F]FDG-PET imaging with a short acquisition time (SAT) and long acquisition time (LAT). Two nuclear medicine physicians (NMPs) reported the presence or absence of GCA according to the overall image impression (gestalt) and total vascular score (TVS) of the cranial arteries. Inter-observer agreement and intra-observer agreement were assessed. (3) Results: In total, 38 patients were included, of whom 20 were diagnosed with GCA and 18 were without it. Sensitivity and specificity for GCA on SAT scans were 80% and 72%, respectively, for the first NMP, and 55% and 89% for the second NMP. On the LAT scans, these values were 65% and 83%, and 75% and 83%, respectively. When using the TVS, LAT scans showed especially increased specificity (94% for both NMPs). Observer agreement was higher on the LAT scans compared with that on the SAT scan. (4) Conclusions: LAT combined with the use of the TVS may decrease the number of false-positive assessments of [18F]FDG PET/CT. Additionally, LAT and TVS may increase both inter and intra-observer agreement. Full article
(This article belongs to the Special Issue Hybrid/Multimodality Cardiovascular Imaging in Large Vessel Vasculitis—2nd Edition)
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