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Diagnostics
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Possibilities of Diagnostic Imaging Modalities in Atypical Parkinsonian Disorders
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Possibilities of Diagnostic Imaging Modalities in Atypical Parkinsonian Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 2967

Special Issue Editors

Dr. Bartosz Migda

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Guest Editor
Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical University of Warsaw, 03-242 Warsaw, Poland
Interests: Parkinson’s disease; neurodegenerative disease; diagnostic imaging
Prof. Dr. Leszek Królicki

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Guest Editor
Department of Nuclear Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland
Interests: Parkinson’s disease; neurodegenerative disease; neurobiology; brain diseases; nuclear medicine imaging
Dr. Piotr Alster

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Guest Editor
Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland
Interests: Parkinson’s disease; atypical parkinsonism; neurodegenerative disease; brain diseases; neuroimaging

Special Issue Information

Dear Colleagues,

Atypical parkinsonisms are a heterogenic group of diseases in terms of symptoms, brain involvement, duration, and prognosis after diagnosis. This group involves: progressive supranuclear palsy (PSP) multiple system atrophy (MSA), and corticobasal syndrome (CBS). Some of these diseases, such as progressive supranuclear palsy and multiple system atrophy, have subtypes, e.g., PSP-RS, PSP-P, MSA-P, and MSA-C, respectively. In the case of progressive supranuclear palsy, those subtypes differ between each other by clinical course, which is less favorable for more common Richardson syndrome (PSP-RS) which is the opposite to parkinsonism predominant (PSP-P).

Most often, the examination of these diseases is conducted by clinical assessment, but in some cases, a post-mortem can be used. Unfortunately, some of those conditions have overlapping clinical manifestations such as PSP and CBS. That is why there is a need to search for new methods of diagnosis, differentiation, and follow-up of these clinical entities.

In the literature currently, there are only a few publications suggesting the usefulness of radiological and nuclear medicine modalities such as MRI, SPECT (single-photon emission-computed tomography), and PET (positron emission tomography), as a solitary method or in combination, in the differentiation of these diseases.

Topics in this Special Issue will include, but are not limited to:

  • Identification of MRI parameters in the differentiation of atypical parkinsonism;
  • Identification of nuclear medicine possibilities in the differentiation of atypical parkinsonism;
  • Finding a correlation between imaging diagnostic parameters and the course of those diseases in clinical practice.

Suggested article types for submission to this Special Issue are:

  • Original research articles;
  • Short communication articles;
  • Reviews.

I look forward to receiving your contributions.

Dr. Bartosz Migda
Prof. Dr. Leszek Królicki
Dr. Piotr Alster
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synucleinopathies
  • tauopathies
  • progressive supranuclear palsy
  • corticobasal degeneration
  • multiple system atrophy
  • magnetic resonance imaging
  • single-photon emission-computed tomography

Published Papers (3 papers)

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Research

11 pages, 8377 KiB  
Article
Differentiation between Parkinson’s Disease and the Parkinsonian Subtype of Multiple System Atrophy Using the Magnetic Resonance T1w/T2w Ratio in the Middle Cerebellar Peduncle
by Jiaqi Wang, Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Tatsuya Yamamoto, Yoshitaka Yamanaka, Nobuyuki Araki, Shoichi Ito, Friedemann Paul and Satoshi Kuwabara
Diagnostics 2024, 14(2), 201; https://doi.org/10.3390/diagnostics14020201 - 17 Jan 2024
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Abstract
Multiple system atrophy with predominant parkinsonism (MSA-P) can hardly be distinguished from Parkinson’s disease (PD) clinically in the early stages. This study investigated whether a standardized T1-weighted/T2-weighted ratio (sT1w/T2w ratio) can effectively detect degenerative changes in the middle cerebellar peduncle (MCP) associated with [...] Read more.
Multiple system atrophy with predominant parkinsonism (MSA-P) can hardly be distinguished from Parkinson’s disease (PD) clinically in the early stages. This study investigated whether a standardized T1-weighted/T2-weighted ratio (sT1w/T2w ratio) can effectively detect degenerative changes in the middle cerebellar peduncle (MCP) associated with MSA-P and PD and evaluated its potential to distinguish between these two diseases. We included 35 patients with MSA-P, 32 patients with PD, and 17 controls. T1w and T2w scans were acquired using a 1.5-T MR system. The MCP sT1w/T2w ratio was analyzed via SPM12 using a region-of-interest approach in a normalized space. The diagnostic performance of the MCP sT1w/T2w ratio was compared between the MSA-P, PD, and controls. Patients with MSA-P had significantly lower MCP sT1w/T2w ratios than patients with PD and controls. Furthermore, MCP sT1w/T2w ratios were lower in patients with PD than in the controls. The MCP sT1w/T2w ratio showed excellent or good accuracy for differentiating MSA-P or PD from the control (area under the curve (AUC) = 0.919 and 0.814, respectively) and substantial power for differentiating MSA-P from PD (AUC = 0.724). Therefore, the MCP sT1w/T2w ratio is sensitive in detecting degenerative changes in the MCP associated with MSA-P and PD and is useful in distinguishing MSA-P from PD. Full article
(This article belongs to the Special Issue Possibilities of Diagnostic Imaging Modalities in Atypical Parkinsonian Disorders)
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11 pages, 3591 KiB  
Article
Surface-Based Functional Alterations in Early-Onset and Late-Onset Parkinson’s Disease: A Multi-Modal MRI Study
by Min Wang, Changlian Tan, Qin Shen, Sainan Cai, Qinru Liu and Haiyan Liao
Diagnostics 2023, 13(18), 2969; https://doi.org/10.3390/diagnostics13182969 - 17 Sep 2023
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Abstract
This study used a surface-based method to investigate brain functional alteration patterns in early-onset Parkinson’s disease (EOPD) and late-onset Parkinson’s disease (LOPD) to provide more reliable imaging indicators for the assessment of the two subtypes. A total of 58 patients with Parkinson’s disease [...] Read more.
This study used a surface-based method to investigate brain functional alteration patterns in early-onset Parkinson’s disease (EOPD) and late-onset Parkinson’s disease (LOPD) to provide more reliable imaging indicators for the assessment of the two subtypes. A total of 58 patients with Parkinson’s disease were divided into two groups according to age at onset: EOPD (≤50 years; 16 males and 15 females) and LOPD (>50 years; 17 males and 10 females) groups. Two control groups were recruited from the community: young adults (YC; ≤50 years; 8 males and 19 females) and older adults (OC; >50 years; 12 males and 10 females). No significant differences were observed between the EOPD and YC groups or the LOPD and OC groups in terms of age, sex, education, and MMSE scores (p > 0.05). No statistically significant differences were observed between the EOPD and LOPD groups in terms of education, H-Y scale, UPDRS score, or HAMD score (p > 0.05). Data preprocessing and surface-based regional homogeneity (2D-ReHo) calculations were subsequently performed using the MATLAB-based DPABIsurf software. The EOPD group showed decreased 2D-ReHo values in the left premotor area and right dorsal stream visual cortex, along with increased 2D-ReHo values in the left dorsolateral prefrontal cortex. In patients with LOPD, 2D-ReHo values were decreased in bilateral somatosensory and motor areas and the right paracentral lobular and mid-cingulate. The imaging characterization of surface-based regional changes may serve useful as monitoring indicators and will help to better understand the mechanisms underlying divergent clinical presentations. Full article
(This article belongs to the Special Issue Possibilities of Diagnostic Imaging Modalities in Atypical Parkinsonian Disorders)
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7 pages, 1634 KiB  
Communication
The Role of the Evans Index and the Maximal Width of the Frontal Horns of the Lateral Ventricles in the Diagnostic Imaging of Progressive Supranuclear Palsy and Multiple-System Atrophy
by Michał Kutyłowski, Piotr Alster, Natalia Madetko-Alster, Anna Marta Migda, Leszek Królicki and Bartosz Migda
Diagnostics 2023, 13(16), 2711; https://doi.org/10.3390/diagnostics13162711 - 20 Aug 2023
Cited by 1 | Viewed by 1167
Abstract
Progressive Supranuclear Palsy and Multiple-System Atrophy are entities within the spectrum of atypical parkinsonism. The role of imaging methods in the diagnosis and differentiation between PSP and MSA is limited and Magnetic Resonance Imaging (MRI) is currently used as a reference modality. In [...] Read more.
Progressive Supranuclear Palsy and Multiple-System Atrophy are entities within the spectrum of atypical parkinsonism. The role of imaging methods in the diagnosis and differentiation between PSP and MSA is limited and Magnetic Resonance Imaging (MRI) is currently used as a reference modality. In this study, the authors examined a group of patients with atypical parkinsonism using a 1.5 T MRI system and aimed to find simple and repeatable measurements that may be useful to distinguish between these diseases. The results of the study indicate that the maximal width of the frontal horns of the lateral ventricles and Evans’ Index may, to some extent, be useful as basic and simple measurements in the diagnostic imaging of patients with atypical parkinsonism. Full article
(This article belongs to the Special Issue Possibilities of Diagnostic Imaging Modalities in Atypical Parkinsonian Disorders)
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