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Diagnostics
Special Issues
Clinical Applications and Potential of Magnetic Resonance Spectroscopy
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Clinical Applications and Potential of Magnetic Resonance Spectroscopy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1036

Special Issue Editor

Dr. Jimin Ren

E-Mail Website
Guest Editor
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States
Interests: Magnetic resonance spectroscopy; brain metabolism; skeletal muscle metabolism; chemical exchange

Special Issue Information

Dear Colleagues,

Magnetic resonance spectroscopy has been increasingly used as a non-invasive modality in clinical applications. This Special Issue will collect recent development of MRS and MRSI in clinical research including, but not limited to, the assessment of ATP energy metabolism, redox state, (de)myelination, neurodegeneration, inflammation, ischemia and oxygenation, cellularity and atrophy, fat infiltration, mineral metabolism, kinetic and dynamic processes, metabolic pathways and intermediates, organ preservation and transplant viability, sex hormonal effects, exercise and fatigue, muscle fiber typing, transmembrane processes, membrane fluidity, mitochondrial (dys)function, and biomarkers of various diseases. Major body organs include brain, heart, liver, kidney, prostate, bone marrow, subcutaneous tissue, and skeletal muscle. Original work on 31P and 13C MRS and collaborative contributions from multiple institutes and using different modalities are especially encouraged.

Dr. Jimin Ren
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic resonance spectroscopy
  • metabolite
  • lipids and phospholipids
  • brain
  • skeletal muscle

Published Papers (1 paper)

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Research

16 pages, 2777 KiB  
Article
17β-Estradiol Effects in Skeletal Muscle: A 31P MR Spectroscopic Imaging (MRSI) Study of Young Females during Early Follicular (EF) and Peri-Ovulation (PO) Phases
by Jimin Ren, Luis Rodriguez II, Talon Johnson, Anke Henning and Yasin Y. Dhaher
Diagnostics 2024, 14(3), 235; https://doi.org/10.3390/diagnostics14030235 - 23 Jan 2024
Viewed by 832
Abstract
The natural variation in estrogen secretion throughout the female menstrual cycle impacts various organs, including estrogen receptor (ER)-expressed skeletal muscle. Many women commonly experience increased fatigue or reduced energy levels in the days leading up to and during menstruation, when blood estrogen levels [...] Read more.
The natural variation in estrogen secretion throughout the female menstrual cycle impacts various organs, including estrogen receptor (ER)-expressed skeletal muscle. Many women commonly experience increased fatigue or reduced energy levels in the days leading up to and during menstruation, when blood estrogen levels decline. Yet, it remains unclear whether endogenous 17β-estradiol, a major estrogen component, directly affects the energy metabolism in skeletal muscle due to the intricate and fluctuating nature of female hormones. In this study, we employed 2D 31P FID-MRSI at 7T to investigate phosphoryl metabolites in the soleus muscle of a cohort of young females (average age: 28 ± 6 years, n = 7) during the early follicular (EF) and peri-ovulation (PO) phases, when their blood 17β-estradiol levels differ significantly (EF: 28 ± 18 pg/mL vs. PO: 71 ± 30 pg/mL, p < 0.05), while the levels of other potentially interfering hormones remain relatively invariant. Our findings reveal a reduction in ATP-referenced phosphocreatine (PCr) levels in the EF phase compared to the PO phase for all participants (5.4 ± 4.3%). Furthermore, we observe a linear correlation between muscle PCr levels and blood 17β-estradiol concentrations (r = 0.64, p = 0.014). Conversely, inorganic phosphate Pi and phospholipid metabolite GPC levels remain independent of 17β-estradiol but display a high correlation between the EF and PO phases (p = 0.015 for Pi and p = 0.0008 for GPC). The robust association we have identified between ATP-referenced PCr and 17β-estradiol suggests that 17β-estradiol plays a modulatory role in the energy metabolism of skeletal muscle. Full article
(This article belongs to the Special Issue Clinical Applications and Potential of Magnetic Resonance Spectroscopy)
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