Early Stage NSCLC: New Age Paradigms
A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Thoracic Oncology".
Deadline for manuscript submissions: 15 August 2024 | Viewed by 182
Special Issue Editors
Interests: thymoma; thymic epithelial tumor; thymus neoplasms; lung cancer
Interests: immunotherapy; target therapy; chemotherapy; radiotherapy; early stage NSCLC; SCLC; study with innovative drugs; thoracic neoplasms
Interests: immunotherapy; target therapy; chemotherapy; radiotherapy; early stage NSCLC; SCLC; study with innovative drugs; thoracic neoplasms
Interests: immunotherapy; target therapy; chemotherapy; radiotherapy; early stage NSCLC; liquid biopsy; thoracic neoplasms; SCLC
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Special Issue Information
Dear Colleagues,
As randomized trials demonstrate the efficacy of new therapeutic approaches in early stage NSCLC, all current treatment paradigms will need to be critically reviewed and many therapeutic strategies that have been used for years will soon need to be modified.
Namely, peri-operative immuno-chemotherapy has shown significant improvement in patient outcomes and will become a routinary treatment strategy for many patients with localized disease, raising questions about the timing and duration of treatment based on multiple variables. Moreover, the efficacy of EGFR TKI in adjuvant settings has been well established, and many trials targeting other actionable targets are ongoing.
These new data also lead to the anticipation of molecular features (NGS) and PD(L)1 analyses compared to current practice, which imposes a different diagnostic logarithm before surgery.
Once all staging and molecular data will be available, a multidisciplinary team will have to decide whether a patient can be considered suitable for surgery or not, as the decision algorithms will be different and it will not be possible to defer this assessment to a later stage.
In this Special Issue, we will analyze the results of the most important studies and discuss their therapeutic implications as well as the changes required in diagnostic and therapeutic strategy.
Some of these consideration will concern the following:
- The need to test molecular tumor features at the time of diagnosis for a multidisciplinary decision-making process;
- Criteria to select individualized peri-operative treatment strategy both pre- and/or after surgery, if surgery is required;
- The variables that the multidisciplinary team will have to take into account in order to set up a correct treatment strategy.
Prof. Dr. Tommaso Martino Martino De Pas
Dr. Chiara Catania
Dr. Claudia Proto
Dr. Alessandro Russo
Guest Editors
Manuscript Submission Information
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Keywords
- immunotherapy
- target therapy
- chemotherapy
- radiotherapy
- early stage NSCLC
