Wet Chemical Synthesis of Functional Materials for Biomedical Applications

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Hybrid and Composite Crystalline Materials".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 1036

Special Issue Editors


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Guest Editor
Biomaterials Research Group, Łukasiewicz Research Network–Institute of Ceramics and Building Materials, Center of Ceramic and Concrete in Warsaw, Cementowa 8, 31-983 Kraków, Poland
Interests: calcium phosphates (CaPs) ceramics; hydroxyapatite (HAp); hydrothermal synthesis; calorimetry; thermochemistry; physical chemistry; biomaterials; material characterization; wet participation synthesis; sonochemical synthesis; bioactive compounds; uracil derivatives

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Guest Editor
State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Interests: bioceramic; apatite; luminescence; nanocrystal; nanomedicine

Special Issue Information

Dear Colleagues,

Functional materials, which manifest in the forms of nanostructures, composites and hybrids, have showed great potential for use in biomedical applications. Over the years, various wet chemical methods, such as solvothermal synthesis, template synthesis, sonochemical synthesis, seeded growth, self-assembly, oriented attachment, and surfactant-mediated synthesis, have been developed in order to synthesize such a varied array of functional materials. Through wet chemical synthesis, it is possible to achieve selective surface structures, phases, shapes, and sizes of high-quality crystalline materials, a process that can lead to a set of desired properties being attained. Wet chemical synthesis routes allow for fine-tuning of the reaction conditions (temperature, time, concentration of substrate, additives or surfactants, pH, etc.) to achieve the desired performances. However, solution-based technologies still require improvements in order to fully compete with other physical techniques widely used in producing high-quality nanomaterials, and also to overcome some of the current limitations for use in academia and industry.

This Special Issue aims to address the recent developments in biomedical applications of functional materials prepared by different wet chemical methods. We invite you to submit your recent research articles or reviews that cover the state of the art and promote future trends in this field.

Dr. Piotr Szterner
Dr. Yingchao Han
Guest Editors

Manuscript Submission Information

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Keywords

  • wet chemical methods
  • solvothermal synthesis
  • template synthesis
  • sonochemical synthesis
  • seeded growth
  • functional materials
  • biomedical applications

Published Papers (1 paper)

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Research

16 pages, 4821 KiB  
Article
Ultrasonically Prepared Sodium Heparin-Stabilized Indocyanine Green/Nano-Hydroxyapatite Suspension for Collaborative Photodynamic and Photothermal Tumor Therapy
by Qifa Song, Zi-You Ding, Chengyu Li, Yiran Fan, Xinli Tang and Yingchao Han
Crystals 2023, 13(9), 1387; https://doi.org/10.3390/cryst13091387 - 18 Sep 2023
Viewed by 806
Abstract
Indocyanine green (ICG) shows promise for diagnosing and treating tumors due to its good photothermal and fluorescent properties. In this study, sodium heparin (SH)-stabilized ICG/nano-hydroxyapatite (SH-ICG/nHAP) suspension was ultrasonically prepared to achieve photothermal and photodynamic collaborative therapy (PTT/PDT) for treating tumors. The nHAP [...] Read more.
Indocyanine green (ICG) shows promise for diagnosing and treating tumors due to its good photothermal and fluorescent properties. In this study, sodium heparin (SH)-stabilized ICG/nano-hydroxyapatite (SH-ICG/nHAP) suspension was ultrasonically prepared to achieve photothermal and photodynamic collaborative therapy (PTT/PDT) for treating tumors. The nHAP had a short rod-like shape and a drug-loading capacity of 13.3% for ICG, corresponding to a drug-loading efficiency of 88.6%. In addition, the SH-ICG/nHAP suspension showed a very low release of ICG in PBS (7.4) and a slightly improved release in acidic buffers (6.5, 5.5), indicating an excellent binding ability of nHAP for ICG. The resulting SH-ICG/nHAP showed good suspension stability. Under an 808 nm near-infrared (NIR) laser, SH-ICG/nHAP showed good photothermal properties and could produce reactive oxygen species (ROS). Under the irradiation of an 808 nm NIR laser at 0.8 W/cm2 for 5 min, SH-ICG/nHAP was found to significantly inhibit HepG2 cells proliferation (78.58%), similar to free ICG. In vivo, SH-ICG/nHAP was found to exert an improved inhibitory effect on tumor growth compared to free ICG. Biocompatible and stable SH-ICG/nHAP suspension like this could be a promising system for the PTT/PDT of tumors. Full article
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