Molecular Insights into Melanogenesis and Melanoma Development
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 86
Special Issue Editor
Special Issue Information
Dear Colleagues,
The main function of melanin is protection from photodamage induced by UV irradiation. However, it also regulates the processes that affect the behavior of melanoma. Melanoma is the most aggressive skin cancer, with a growing number of incidents worldwide and no effective cure in the metastatic stage so far. The pathway responsible for melanin synthesis differs in normal and malignant melanocytes. Melanocyte transformation occurs when DNA repair or cell-cycle control mechanisms are damaged. In most cases, melanocyte transformation results in a benign melanocytic neoplasm (such as a naevus) forming. In malignant melanocytes, the process of melanogenesis is frequently upregulated, suggesting possible therapeutic targets. The etiology of melanoma or naevi is complex and heterogeneous, constituting an interplay between the environment, a person's phenotype, and genetic risk, along with acquired molecular alterations.
There are several pathways and processes engaged in melanoma pathogenesis that have been extensively explored in recent years. However, the mechanism and precise impact of melanin on melanoma progression is still not clear.
In this Issue, we aim to highlight the use of current technologies for the discovery of new melanoma susceptibility genes, new molecular targets for therapy, and novel pathways to understand melanogenesis and melanoma development. Original research articles and review papers are very welcome.
Dr. Urszula Kazimierczak
Guest Editor
Manuscript Submission Information
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Keywords
- melanoma
- genetics
- genomics
- biomarkers
- melanoma pathology
- RNA
- biomarkers and molecular inhibitors
