Recent Developments in Wearable Sensors for Biomedical and Healthcare Applications

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3330

Special Issue Editor

Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion−Israel Institute of Technology, Haifa 3200003, Israel
Interests: sensors; nanomaterials; volatolomics; volatile organic compounds; diagnostics; breath analysis; electronic nose; GC–MS; cancer; infectious diseases; homeland security; forensics; food analysis; environmental analysis; chemical communication
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Special Issue Information

Dear Colleagues,

Biosensors and chemical sensors have been gaining interest in recent years due to their promising integration into healthcare systems and health monitoring.

Thanks to advanced functional (bio)materials, together with micro- and nanotechnology, state-of-the-art sensing approaches contain adequate hard-wired intelligence and robustness that provides a collection of data/analyses to the expert. Applicability and user-friendliness are at the core of these sensing technologies.

The health technology market has been affected by the increase in patients’ self-measurements, “point of care” tests, and remote disease monitoring, particularly during the recent COVID-19 pandemic. For this reason, it is essential to have low-cost, easy-to-use, and effective solutions and to design new healthcare technologies.

Consequently, the performance of sensing devices depends heavily on the proper sensing characteristics of their integrated sensing parts.

This Special Issue will be dedicated to the didactic examination of the concepts and approaches related to the emerging chemistries, sensing materials, and transduction techniques in novel wearable devices used for biomarker-based sensing, IoT, and solutions for medical evaluations.

Dr. Yoav Broza
Guest Editor

Manuscript Submission Information

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Keywords

  • chemosensors
  • biosensors
  • point-of-care sensing
  • health monitoring
  • diagnostic sensors
  • wearable sensors
  • IoT solutions for sensing technologies
  • medical devises
  • biointerfaced sensors
  • hybrid sensors
  • volatile organic compounds
  • epidermal
  • implantable
  • healthy life
  • biodiagnostics

Published Papers (2 papers)

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Research

13 pages, 1883 KiB  
Article
Low-Cost, High-Sensitivity Paper-Based Bacteria Impedance Sensor Based on Vertical Flow Assay
by Yifan Long, Zhehong Ai, Longhan Zhang, Han Zhang, Jing Jiang and Gang Logan Liu
Chemosensors 2023, 11(4), 238; https://doi.org/10.3390/chemosensors11040238 - 11 Apr 2023
Viewed by 1442
Abstract
This study proposes a low-cost, portable paper-fluidic vertical flow assay bacterium counter with high accuracy. We designed sensors with low fabrication costs based on e-beam evaporation and three-dimensional printing based on the impedance measurement principle. Interdigitated (IDT) electrodes were coated on the filter [...] Read more.
This study proposes a low-cost, portable paper-fluidic vertical flow assay bacterium counter with high accuracy. We designed sensors with low fabrication costs based on e-beam evaporation and three-dimensional printing based on the impedance measurement principle. Interdigitated (IDT) electrodes were coated on the filter membrane by e-beam evaporation with a shadow mask. We could print wafer-scale frames with low melting temperature three-dimensional-printing materials for confining liquid bacterial samples within the IDT sensing region. This novel fabrication technique significantly reduced the chip’s cost to less than 1% of that of silicon-based chips. Two equivalent circuit models were proposed for different concentration ranges to analyze the principle of paper-based impedance bacterial sensors. We proposed an improved model based on the Randles model for low concentrations by considering the leaky double-layer capacitor effect and spherical diffusion from the nano-structural electrodes of the gold-coated filter membrane. The phenomenon in which charge transfer resistance, Rct, declines at high concentration ranges was found and explained by the pearl chain effect. The pearl effect could cause a false-negative at high concentrations. We modeled the pearl chain effect as an R and C, connected parallel to the low-concentration model. When users properly applied both models for analyses, this sensor could quantitatively measure cell concentrations from 400 to 400 M per milliliter with superior linearity. Full article
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10 pages, 2388 KiB  
Communication
Poly(acrylic acid)/Dipeptide Double-Network Hydrogel to Achieve a Highly Stretchable Strain Sensor
by Xin Luo, Boya Ding and Xingcen Liu
Chemosensors 2022, 10(9), 360; https://doi.org/10.3390/chemosensors10090360 - 09 Sep 2022
Viewed by 1579
Abstract
Flexible and stretchable strain sensors can be applied for human health monitoring and disease diagnoses via the output of multiple biophysical signals. However, it is still a challenge to fabricate short-peptide-based strain sensors. Here, we prepared a novel polymer-dipeptide double-network hydrogel with excellent [...] Read more.
Flexible and stretchable strain sensors can be applied for human health monitoring and disease diagnoses via the output of multiple biophysical signals. However, it is still a challenge to fabricate short-peptide-based strain sensors. Here, we prepared a novel polymer-dipeptide double-network hydrogel with excellent stretchability, responsiveness, and stability. The poly(acrylic acid) (PAA) gel, by cross-linking, maintains mechanical and flexible properties, and the fluorenyl methoxycarbonyl-diphenylalanine (Fmoc-FF) network, by non-covalent interactions, is helpful for energy dissipation. With increasing tensile or compression strains, the PAA/Fmoc-FF hydrogel exhibited a high mechanical strength and fast recovery. Moreover, as the presence of KCl improves the electronic conductivity, the hybrid gel exhibited a cyclic strain-stress performance, which is the foundation of a strain sensor. Based on that, its application as a motion sensor was demonstrated by monitoring the movements of human joints, such as the forefinger, wrist, elbow, and knee. Consequently, the hybrid polymer-peptide gel could be an ideal candidate for wearable sensors in the future. Full article
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