What Is New in the Treatment of Intraocular (Uveal) Melanoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 October 2024 | Viewed by 1090

Special Issue Editors


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Guest Editor
Department of Radiation Oncology, Duke University, Durham, NC 27710, USA
Interests: plaque brachytherapy; uveal melanoma; eye physics; plaque simulator

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Guest Editor
Departments of Ophthalmology, Duke University, Durham, NC 27710, USA
Interests: eye cancer; retinoblastoma; ocular tumors; uveal melanoma
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Radiation Oncology, Duke University, Durham, NC 27710, USA
Interests: plaque brachytherapy; uveal melanoma; eye physics; plaque simulator

Special Issue Information

Dear Colleagues, 

Uveal, or intraocular, melanoma is the most common type of primary eye cancer in adults that begins in the uveal tract (iris, ciliary body, or choroid), and impacts most often older persons with fair skin and light-colored eyes more frequently. Although uveal melanoma is straightforward to diagnose via eye examinations, it has a high risk of migrating to other parts of the body, and an especially high risk of metastasizing in the liver. There are several courses of treatment depending on the size and history of the tumor. These may include surgery such as resection, enucleation, or exenteration, or radiation therapy through either external therapy (photon or proton beams) or internal therapy (plaque brachytherapy). Other treatments may include transpupillary thermotherapy, and new plaque-based and drug treatments.

Dr. Sheridan Meltsner
Prof. Dr. Miguel A. Materin
Dr. Oana Craciunescu
Guest Editors

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Keywords

  • uveal melanoma
  • plaque brachytherapy
  • ocular tumors
  • proton therapy
  • transpupillary thermotherapy
  • molecular prognostication
  • gene expression

Published Papers (1 paper)

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15 pages, 1055 KiB  
Review
Current and Emerging Radiotherapy Options for Uveal Melanoma
by Oleksii Semeniuk, Esther Yu and Mark J. Rivard
Cancers 2024, 16(5), 1074; https://doi.org/10.3390/cancers16051074 - 06 Mar 2024
Viewed by 749
Abstract
What treatment options are there for patients having uveal melanoma? A randomized, prospective, multi-institutional clinical trial (COMS) showed no difference in survival between brachytherapy and enucleation for medium-sized lesions. With the obvious benefit of retaining the eye, brachytherapy has flourished and many different [...] Read more.
What treatment options are there for patients having uveal melanoma? A randomized, prospective, multi-institutional clinical trial (COMS) showed no difference in survival between brachytherapy and enucleation for medium-sized lesions. With the obvious benefit of retaining the eye, brachytherapy has flourished and many different approaches have been developed such as low-dose-rate sources using alternate low-energy photon-emitting radionuclides, different plaque designs and seed-loading techniques, high-dose-rate brachytherapy sources and applicators, and low- and high-dose-rate beta-emitting sources and applicators. There also have been developments of other radiation modalities like external-beam radiotherapy using linear accelerators with high-energy photons, particle accelerators for protons, and gamma stereotactic radiosurgery. This article examines the dosimetric properties, targeting capabilities, and outcomes of these approaches. The several modalities examined herein have differing attributes and it may be that no single approach would be considered optimal for all patients and all lesion characteristics. Full article
(This article belongs to the Special Issue What Is New in the Treatment of Intraocular (Uveal) Melanoma)
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