Special Issue "Current Management of Castration-Resistant Prostate Cancer (CRPC)"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 13930
Interests: genitourinary cancers; serum biomarkers; prognostic and predictive biomarkers; castration-resistant prostate cancer; anti-hormonal therapy; immunotherapy; clinical trials; liquid biopsy; drug development
In recent years, the treatment of castration-resistant prostate cancer has witnessed dramatic advances. Currently, the inhibition of androgen receptor signaling, chemotherapy, and radioligand therapies in various sequences are the mainstay of therapy. However, sooner or later, primary or secondary resistance against any given therapy inevitably occurs. Reasons for this include sustained proliferative androgen receptor signaling, activating point mutations of the androgen receptor, alternative splicing of the androgen receptor, cell cycle activation, evading apoptosis, inducing angiogenesis, activating invasion and metastasis, defective DNA-repair machinery, evasion of immune control, and many more. All of these occur in the context of chronic inflammation and genomic instability. Castration-resistant prostate cancer is still uncurable, and accounts for nearly all prostate cancer-related deaths. Understanding the genetic and biological mechanisms leading to therapy resistance and sustaining progression is crucial to achieving further advances in the sequencing of available drugs and management of castration-resistant prostate cancer in general. Any experimental and clinical work potentially relevant to this Special Issue will be carefully considered for inclusion.
Prof. Dr. Martin Bögemann
Prof. Dr. Tilman Todenhöfer
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- therapy sequencing
- predictive biomarkers
- prognostic biomarkers
- treatment resistance
- androgen receptor