Special Issue "Molecular and Cellular Changes in the Formation of Tumor-Initiating Cells"
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5611
2. Division of Genetics, Brigham and Women’s Hospital, Boston, MA 02115, USA
Interests: cellular origin of cancer; stem cell and cancer; premalignant and tumor microenvironment; mouse models of human cancer; developmental oncobiology; breast cancer; ovarian cancer; prostate cancer; mammary gland biology
Tumor-Initiating Cells (TICs), also known as Cancer Stem Cells, refer to a subset of cancer cells capable of self-renewal proliferation and producing all other cancer cell types within a tumor. The concept of TICs is originally a functional definition, largely based on transplantation assays. The term TICs is now more widely used in cancer biology, often referring to or overlapping with cellular origin of cancer, most recent common ancestor of cancer (based on sequencing data), cancer cells with stem cell-like properties, therapy-resistant cancer cells, or metastasis-initiating cells. Nevertheless, TICs represent a key subset of cancer cells responsible for cancer initiation, progression, metastasis, and therapy resistance; therefore, a better mechanistic understanding of their formation would be essential for developing novel strategies of cancer prevention and therapy, and for overcoming therapy resistance.
The purpose of this Special Issue is to define molecular and cellular changes leading to the formation of TICs, including 1) genetic basis and/or epigenetic mechanism of TIC formation; 2) contribution of environmental factors (e.g., immune cells) to TIC formation; 3) drug resistance and TICs; 4) formation of metastasis-initiating cells; 5) emerging technology for studying TICs. This Special Issue welcomes both original research articles and reviews.
Dr. Zhe Li
Manuscript Submission Information
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- cancer stem cell
- stem cell and cancer
- cellular origin of cancer
- tumor microenvironment
- immune mechanism
- most recent common ancestor of cancer
- metastasis-initiating cell
- cellular basis of cancer therapy resistance
- genetic and epigenetic basis of tumor initiation
- tumor cell heterogeneity