Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2034

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
Liver Diseases Prevention and Treatment Center, Dalin Tzu Chi Hospital, Chia-Yi and School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan
Interests: liver cancer; viral hepatitis; fatty liver; liver cirrhosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Gastroenterology, Division of Internal Medicine, Jen-Ai Hospital, Taichung 412224, Taiwan
2. Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan
Interests: hepatology; liver cancer; liver tumor biopsy and ablation; contrast ultrasound
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
2. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Interests: hepatocellular carcinoma

Special Issue Information

Dear Colleagues, 

The carcinogenesis of HCC is a complex process that is associated with the aberrant activation of various cellular and molecular pathways and the disruption of balance between the activation and inactivation of protooncogenes and tumor suppressor genes, respectively. During the past few decades, advancements in molecular cell biology have improved our understanding of the detailed molecular mechanisms underlying tumor initiation and progression‚ contributing to the evolution of strategies for prevention, surveillance, early diagnosis, and treatment. At present, many clinical trials that examine the use of molecular-targeted therapies that inhibit the growth of tumor cells by interfering with the molecular mechanisms of HCC carcinogenesis have shown promising results. In this Special Issue of Cancers, we will include original or review articles concerning “tumor suppressor” or “targeted therapy” in hepatocellular carcinoma. The Editor and Co-editors will monitor and select the best articles regarding subjects such as clinical screening, genetic testing, diagnosis, treatments, and the prevention of complications in patients with hepatocellular carcinoma.

Prof. Dr. Ching-Sheng Hsu
Dr. Po-Heng Chuang
Dr. I-Cheng Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor suppressor
  • targeted therapy
  • hepatocellular carcinoma
  • human
  • diagnosis
  • surveillance
  • complication
  • early detection
  • carcinogenesis

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

15 pages, 1105 KiB  
Systematic Review
Atezolizumab and Bevacizumab Combination Therapy in the Treatment of Advanced Hepatocellular Cancer
by Ignacio Ventura, Lorena Sanchiz, María Ester Legidos-García, María Teresa Murillo-Llorente and Marcelino Pérez-Bermejo
Cancers 2024, 16(1), 197; https://doi.org/10.3390/cancers16010197 - 30 Dec 2023
Cited by 1 | Viewed by 1410
Abstract
Liver cancer, particularly hepatocellular carcinoma, is a global concern. This study focuses on the evaluation of Atezolizumab and Bevacizumab combination therapy as a promising alternative in the treatment of advanced hepatocellular carcinoma. The objectives of this systematic review include evaluating the efficacy of [...] Read more.
Liver cancer, particularly hepatocellular carcinoma, is a global concern. This study focuses on the evaluation of Atezolizumab and Bevacizumab combination therapy as a promising alternative in the treatment of advanced hepatocellular carcinoma. The objectives of this systematic review include evaluating the efficacy of Atezolizumab and Bevacizumab combination therapy compared to conventional therapies with Sorafenib and other conventional therapies, analyzing the associated adverse effects, and exploring prognostic factors in the setting of advanced hepatocellular carcinoma. A systematic literature review was carried out using the PubMed and Web of Science databases. Fifteen related articles were included and evaluated according to their level of evidence and recommendation. Results: The combination therapy of Atezolizumab and Bevacizumab, along with Sorafenib, showed positive results in the treatment of patients with advanced hepatocellular carcinoma. Significant adverse effects were identified, such as gastrointestinal bleeding, arterial hypertension, and proteinuria, which require careful attention. In addition, prognostic factors, such as transforming growth factor beta (TGF-β), alpha-fetoprotein (AFP), and vascular invasion, were highlighted as key indicators of hepatocellular carcinoma progression. Conclusions: The combination of Atezolizumab and Bevacizumab is shown to be effective in the treatment of advanced hepatocellular carcinoma, although it is essential to take into consideration the associated adverse effects. The prognostic factors identified may provide valuable information for the clinical management of this disease. This study provides a comprehensive overview of a promising emerging therapy for liver cancer. Full article
Show Figures

Figure 1

Back to TopTop