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Cancers
Special Issues
Radiation Dose in Cancer Radiotherapy
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Radiation Dose in Cancer Radiotherapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2366

Special Issue Editor

Prof. Dr. Andrew Nisbet

E-Mail Website
Guest Editor
Department of Medical Physics & Biomedical Engineering, Faculty of Engineering Science, University College London, London, UK
Interests: radiation dosimetry; radiation detectors; radiotherapy treatment planning; radiotherapy technological developments
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

More than half of cancer patients receive radiotherapy as part of their treatment and ongoing developments in the field have ensured that radiotherapy remains a key treatment option. Technological developments have seen the implementation of image guided, high precision treatments such as stereotactic radiosurgery (SRS) and stereotactic ablative radiotherapy (SABR) employing high dose, low fraction treatment regimens. The number of proton and carbon beam therapy facilities continues to rise globally and developments in molecular radiotherapy and brachytherapy have also been seen. Synergistic approaches using biological and immunotherapy agents are also being developed. These approaches have been supported by developments in preclinical investigations in small animal imaging and irradiation (SARP). All of these developments require accurate determination of the radiation dose to ensure clinical outcomes are not compromised. The aim of this special issue is to provide an up to date overview of developments in all aspects of Radiation Dose in Cancer Radiotherapy. 

Prof. Dr. Andrew Nisbet
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiation dosimetry
  • radiation detectors
  • radiotherapy treatment planning
  • radiotherapy technological developments
  • cancer patients

Published Papers (1 paper)

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Research

19 pages, 2596 KiB  
Article
Characterization of Inorganic Scintillator Detectors for Dosimetry in Image-Guided Small Animal Radiotherapy Platforms
by Ileana Silvestre Patallo, Anna Subiel, Rebecca Carter, Samuel Flynn, Giuseppe Schettino and Andrew Nisbet
Cancers 2023, 15(3), 987; https://doi.org/10.3390/cancers15030987 - 03 Feb 2023
Viewed by 1807
Abstract
The purpose of the study was to characterize a detection system based on inorganic scintillators and determine its suitability for dosimetry in preclinical radiation research. Dose rate, linearity, and repeatability of the response (among others) were assessed for medium-energy X-ray beam qualities. The [...] Read more.
The purpose of the study was to characterize a detection system based on inorganic scintillators and determine its suitability for dosimetry in preclinical radiation research. Dose rate, linearity, and repeatability of the response (among others) were assessed for medium-energy X-ray beam qualities. The response’s variation with temperature and beam angle incidence was also evaluated. Absorbed dose quality-dependent calibration coefficients, based on a cross-calibration against air kerma secondary standard ionization chambers, were determined. Relative output factors (ROF) for small, collimated fields (≤10 mm × 10 mm) were measured and compared with Gafchromic film and to a CMOS imaging sensor. Independently of the beam quality, the scintillator signal repeatability was adequate and linear with dose. Compared with EBT3 films and CMOS, ROF was within 5% (except for smaller circular fields). We demonstrated that when the detector is cross-calibrated in the user’s beam, it is a useful tool for dosimetry in medium-energy X-rays with small fields delivered by Image-Guided Small Animal Radiotherapy Platforms. It supports the development of procedures for independent “live” dose verification of complex preclinical radiotherapy plans with the possibility to insert the detectors in phantoms. Full article
(This article belongs to the Special Issue Radiation Dose in Cancer Radiotherapy)
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