Recent Research on Immunotherapy in Ovarian Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 2980

Special Issue Editor


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Guest Editor
Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Université de Montréal, Montreal, QC, Canada
Interests: ovarian cancer; immunotherapy; immune checkpoint; CAR T cells; cancer vaccine; BITE; oncolytic virus

Special Issue Information

Dear Colleagues,

Ovarian cancer remains one of the most lethal of gynaecological malignancies, characterised in most patients by the rapid acquisition of chemo-resistance. Substantial molecular heterogeneity at diagnosis further complicates treatment choices and efficacy. Accordingly, more than 80% of ovarian cancer patients experience recurrent disease and more than 50% of these patients die from the disease in less than five years post-diagnosis. Therefore, there is an urgent need for new treatments.

Immunotherapy has shown potential for ovarian cancer and several clinical trials testing new treatments are currently underway, including immune checkpoint inhibitors, cancer vaccines, oncolytic viruses, bispecific T-cell engagers and engineered cell therapies. Despite this expanding arsenal, there still are no approved immunotherapies for ovarian cancer. In this Special Issue of Cancers, experts in the field will review the current knowledge about ovarian cancer immunotherapy and the barriers that remain for clinical implementation, as well as new research aimed towards more effectively applying immunotherapy to the treatment of ovarian cancer.

Dr. John Stagg
Guest Editor

Manuscript Submission Information

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Keywords

  • ovarian cancer
  • immunotherapy
  • immune checkpoint
  • CAR T cells
  • cancer vaccine
  • BITE
  • oncolytic virus

Published Papers (1 paper)

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Research

13 pages, 1781 KiB  
Article
Methylene Blue Metabolic Therapy Restrains In Vivo Ovarian Tumor Growth
by Jorgelindo da Veiga Moreira, Nancy Nleme, Laurent Schwartz, Kim Leclerc-Desaulniers, Euridice Carmona, Anne-Marie Mes-Masson and Mario Jolicoeur
Cancers 2024, 16(2), 355; https://doi.org/10.3390/cancers16020355 - 13 Jan 2024
Viewed by 2694
Abstract
Ovarian cancer remains a significant challenge, especially in platinum-resistant cases where treatment options are limited. In this study, we investigated the potential of methylene blue (MB) as a metabolic therapy and complementary treatment approach for ovarian cancer. Our findings demonstrated a significant in [...] Read more.
Ovarian cancer remains a significant challenge, especially in platinum-resistant cases where treatment options are limited. In this study, we investigated the potential of methylene blue (MB) as a metabolic therapy and complementary treatment approach for ovarian cancer. Our findings demonstrated a significant in vivo reduction in the proliferation of TOV112D-based ovarian-cell-line xenografts. In this preclinical study, which used a carboplatin-resistant ovarian cancer tumor model implanted into mice, MB-mediated metabolic therapy exhibited superior tumor slowdown compared to carboplatin treatment alone. This indicates, for the first time, MB’s potential as an alternative or adjuvant treatment, especially for resistant cases. Our in vitro study on TOV112D and ARPE-19 sheds light on the impact of such an MB-based metabolic therapy on mitochondrial energetics (respiration and membrane potential). MB showed a modulatory role in the oxygen consumption rate and the mitochondrial membrane potential. These results revealed, for the first time, that MB specifically targets TOV112D mitochondria and probably induces cell apoptosis. The differential response of normal (ARPE-19) and cancer (TOV112D) cells to the MB treatment suggests potential alterations in cancer cell mitochondria, opening avenues for therapeutic approaches that target the mitochondria. Overall, our findings suggest the efficacy of MB as a possible treatment for ovarian cancer and provide valuable insights into the mechanisms underlying the efficacy of methylene blue metabolic therapy in ovarian cancer treatment. Full article
(This article belongs to the Special Issue Recent Research on Immunotherapy in Ovarian Cancer)
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