The Role of Epithelial-Mesenchymal Transition in Therapies Resistance and Cancer Metastasis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 19 January 2025 | Viewed by 763
Special Issue Editor
Special Issue Information
Dear Colleagues,
The epithelial–mesenchymal transition (EMT) is a rapid process involving epithelial cell loosening adhesion structures within a population of polarized and differentiated neighbor cells. These cells loose polarity, strongly remodel their cytoskeleton and engage in a motile individualized phenotype. EMT phases are described in most pluricellular organisms as developmental steps, including during gastrulation, neural crest formation and heart morphogenesis. They are typically controlled by several families of very conserved EMT-associated transcription factors (EMTaTF), emerging first in cnidaria and expressed through the animal kingdom. In cancer, a range of EMT-associated phenotypes can be characterized, in links with progression and metastasis, coupled with specific cellular responses such as stemness, heterogeneity and resistance to treatment and immune response. The EMT International Association (TEMTIA) was founded 20 years ago to study all aspects of EMT, embracing physiological and cancer-related EMT occurrences. The last symposium took place last November in Paris, France. It included speakers from various relevant fields, including developmental biology, cancer, metabolism, immune response and evolutionary biology. This Special Issue will report the main new findings and the new emerging concepts and perspectives, directly from the speakers.
Dr. Pierre Savagner
Guest Editor
Manuscript Submission Information
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Keywords
- epithelial-mesenchymal transition
- plasticity
- resistance
- immune response
- stemness
- invasion
- metabolism
- metastasis
- development
