Blood Stem Cell and Hematological Malignancies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 821
Special Issue Editor
2. Department of Pathology and Laboratory Medicine, The University of Tennessee, Memphis, TN 38163, USA
Interests: hematopoietic stem and progenitor cells; single-cell dynamics; cell fate decisions; asymmetric cell division; cell polarity; lysosomes; mitochondria
Special Issue Information
Dear Colleagues,
Hematopoietic stem cells (HSCs) are critical for the lifelong production of blood. This rare, tissue-specific stem cell resides in the bone marrow, promoting the release of mature blood cells and self-renewing to produce novel HSCs. Because of their unique properties, HSCs are the foundation of regenerative medicine and are used to reconstitute the entire hematopoietic system in hematopoietic stem cell transplants. Once transplanted, hematopoietic stem cells replace or complement the hematopoietic system in patients, a process which is often the only curative therapy for many blood diseases. While HSCs can cure diseases, many hematological diseases begin with mutations in HSCs. Mutations in HSCs can provide a fitness advantage, allowing mutant HSCs to outcompete their normal counterparts over time. Competition between different HSC clones leads to subtle changes in hematopoiesis at first and accelerates with time as mutant HSC clones expand and acquire additional mutations. Although clonal evolution ultimately drives the progression of every disease, the process itself is still poorly understood. A better understanding of hematopoietic stem cell biology in health and disease is thus needed to prevent and delay clonal evolution, limit disease progression, and develop better treatments.
In this Special Issue, we are pleased to invite you to contribute your latest findings, share exciting novel insights, and summarize the current research of your field of research. This Special Issue aims to highlight recent research advances in hematopoietic stem cell biology, including their role in hematological malignancies, clonal hematopoiesis, myelodysplastic syndromes, and the part played by cell-intrinsic vs. cell-extrinsic factors in disease progression. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following areas:
- Hematopoietic stem cells;
- Clonal hematopoiesis;
- Hematological malignancies;
- Bone marrow failures;
- Translational research.
We look forward to receiving your contributions.
Dr. DIrk Loeffler
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hematopoietic stem cells
- hematological malignancies
- clonal hematopoiesis
- clonal evolution
- preleukemia and leukemia
- self-renewal and differentiation
- asymmetric cell division
- cell polarity
- therapy resistance
- transformation
