Research on Ocular and Intraocular Tumors

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 3957

Special Issue Editors


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Guest Editor
Department of Ophthalmology, Dessau Hospital, Brandenburg Medical School Theodor Fontane, Auenweg 38, 06847 Dessau, Germany
Interests: uveal melanoma; ocular lymphoma; radiosurgery

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Guest Editor
Departments of Radiation Oncology, Dessau Hospital, Brandenburg Medical School Theodor Fontane, Auenweg 38, 06847 Dessau, Germany
Interests: uveal melanoma; ocular lymphoma; radiosurgery; combined modality treatment; precision medicine

Special Issue Information

Dear Colleagues,

Eye tumors are associated with the threat of losing sight or the eye itself, and are often associated with considerable distress for the patients. Each year, 1 out of every 100,000 individuals will be affected by a primary tumor.

Tumors of the eye are classified as orbital or intraocular neoplasia. Orbital diseases include lymphoma and metastasis. Primary orbital tumors are rare, such as cconjunctival melanoma, and are often difficult to treat, with high rates of recurrence and metastasis.

The most common intraocular malignancies are metastases, mostly from breast, lung or gastrointestinal cancers; effective systemic therapy usually achieves good intraocular disease control.

Choroidal melanoma has the highest prevalence of all primary intraocular tumors. Primary disease control and eye preservation are achieved in most patients, because effective and complementary treatment strategies, ascertaining to local tumor control, exist. Classically, brachytherapy with iodine or ruthenium plaques, proton therapy, or radiosurgery with photons are commonly being employed. Metastatic spread, however, has remained challenging and therapeutic options remain limited, although important progress has been made with immunotherapies in recent years.

The current Special Issue of Cancers is set to highlight novel developments in translational medicine, organ-preserving therapies for intraocular tumors, and innovative strategies regarding how to most appropriately deal with metastatic disease.

Dr. Lothar Krause
Dr. Ilja Frank Ciernik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular oncology
  • choroidal melanoma
  • choroidal metastasis
  • retinoblastoma
  • lymphoma
  • conjunctival melanoma
  • brachytherapy
  • proton therapy
  • radiosurgery

Published Papers (2 papers)

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Research

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20 pages, 4592 KiB  
Article
Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
by Su-Chan Lee, Lujain Alaali, HyukJean Kwon, Mohammed Rigi and Charles G. Eberhart
Cancers 2022, 14(13), 3122; https://doi.org/10.3390/cancers14133122 - 25 Jun 2022
Cited by 4 | Viewed by 1921
Abstract
Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3′-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of several types of cancer. [...] Read more.
Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3′-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of several types of cancer. However, the effects of cordycepin have only been examined in a limited number of tumor types, and its mechanism of action is poorly understood. We found that cordycepin slows the growth and promotes apoptosis in uveal melanoma, as well as a range of other hard-to-treat malignancies, including retinoblastoma, atypical teratoid rhabdoid tumors, and diffuse midline gliomas. Interestingly, these effects were dependent on low adenosine deaminase (ADA) expression or activity. Inhibition of ADA using either siRNA or pharmacologic approaches sensitized tumors with higher ADA to cordycepin in vitro and in vivo, with increased apoptosis, reduced clonogenic capacity, and slower migration of neoplastic cells. Our studies suggest that ADA is both a biomarker predicting response to cordycepin and a target for combination therapy. We also describe a novel mechanism of action for cordycepin: competition with adenosine triphosphate (ATP) in binding to Hsp90, resulting in impaired processing of oncogenic Hsp90 client proteins. Full article
(This article belongs to the Special Issue Research on Ocular and Intraocular Tumors)
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11 pages, 284 KiB  
Review
Update in Molecular Testing for Intraocular Lymphoma
by Michael J. Heiferman, Michael D. Yu and Prithvi Mruthyunjaya
Cancers 2022, 14(19), 4546; https://doi.org/10.3390/cancers14194546 - 20 Sep 2022
Cited by 3 | Viewed by 1541
Abstract
The diagnosis of primary vitreoretinal lymphoma and central nervous system lymphoma is challenging. In cases with intraocular involvement, vitreous biopsy plays a pivotal role. Several diagnostic tests are employed to confirm a diagnosis and include cytologic evaluation, immunohistochemistry, flow cytometry, and cytokine analysis. [...] Read more.
The diagnosis of primary vitreoretinal lymphoma and central nervous system lymphoma is challenging. In cases with intraocular involvement, vitreous biopsy plays a pivotal role. Several diagnostic tests are employed to confirm a diagnosis and include cytologic evaluation, immunohistochemistry, flow cytometry, and cytokine analysis. The limitations of these conventional diagnostic tests stem from the often paucicellular nature of vitreous biopsy specimens and the fragility of malignant cells ex vivo. Several emerging molecular techniques show promise in improving the diagnostic yield of intraocular biopsy, possibly enabling more accurate and timely diagnoses. This article will review existing diagnostic modalities for intraocular lymphoma, with an emphasis on currently available molecular tests. Full article
(This article belongs to the Special Issue Research on Ocular and Intraocular Tumors)
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