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Cancers
Special Issues
Current Status of Irreversible Electroporation for Colorectal Hepatic Metastases
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Current Status of Irreversible Electroporation for Colorectal Hepatic Metastases

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: closed (22 December 2023) | Viewed by 2390

Special Issue Editor

Dr. Ajith K. Siriwardena

E-Mail Website
Guest Editor
Manchester Royal Infirmary, Manchester, UK
Interests: hepato-pancreatico-biliary surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Approximately one fifth of patients with colorectal cancer present with liver metastases, and some patients will develop further metastases during the course of their disease. The optimal treatment comprises a combination of systemic and loco-regional therapies. Hepatectomy is regarded as the standard of care for patients with resectable liver metastases confined to the liver. However, the ablation of colorectal hepatic metastases has also become accepted as a viable treatment option.  Irreversible electroporation involves the delivery of electrical energy between probes, and has been shown to cause necrosis of liver metastases.  The aim of this Special Issue is to highlight the state of the art of irreversible electroporation in patients with colorectal hepatic metastases.  This issue aims to highlight the current evidence base, provide a snapshot of the use of IRE for treating colorectal liver metastases, address methods of assessing treatment responses, provide guidance on training, and serve as a comprehensive overview of the current status of IRE for treating colorectal liver metastases.

This Special Issue aims to present the current status of irreversible electroporation for use in patients with colorectal liver metastases. As colorectal cancer is a common clinical problem, and as IRE is a treatment that has been available for a number of years, the aim of this issue is to provide a focused overview of this topic.

In this Special Issue, we aim to present systematic reviews of the current use of IRE in patients with colorectal liver metastases, a snapshot of the current use of IRE in patients with colorectal liver metastases, and articles on the assessment of responses to IRE and on training in IRE.

We look forward to receiving your contributions.

Dr. Ajith K. Siriwardena
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • irreversible electroporation
  • colorectal liver metastases
  • ablation
  • liver tumors
  • colorectal cancer

Published Papers (1 paper)

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11 pages, 631 KiB  
Systematic Review
Irreversible Electroporation for Liver Metastases from Colorectal Cancer: A Systematic Review
by Harry V. M. Spiers, Francesco Lancellotti, Nicola de Liguori Carino, Sanjay Pandanaboyana, Adam E. Frampton, Santhalingam Jegatheeswaran, Vinotha Nadarajah and Ajith K. Siriwardena
Cancers 2023, 15(9), 2428; https://doi.org/10.3390/cancers15092428 - 24 Apr 2023
Cited by 2 | Viewed by 2092
Abstract
Background: Irreversible electroporation (IRE) is a non-thermal form of ablation based on the delivery of pulsed electrical fields. It has been used to treat liver lesions, particularly those in proximity to major hepatic vasculature. The role of this technique in the portfolio of [...] Read more.
Background: Irreversible electroporation (IRE) is a non-thermal form of ablation based on the delivery of pulsed electrical fields. It has been used to treat liver lesions, particularly those in proximity to major hepatic vasculature. The role of this technique in the portfolio of treatments for colorectal hepatic metastases has not been clearly defined. This study undertakes a systematic review of IRE for treatment of colorectal hepatic metastases. Methods: The study protocol was registered with the PROSPERO register of systematic reviews (CRD42022332866) and reports in compliance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The Ovid MEDLINE®, EMBASE, Web of Science and Cochrane databases were queried in April 2022. The search terms ‘irreversible electroporation’, ‘colon cancer’, ‘rectum cancer’ and ‘liver metastases’ were used in combinations. Studies were included if they provided information on the use of IRE for patients with colorectal hepatic metastases and reported procedure and disease-specific outcomes. The searches returned 647 unique articles and the exclusions left a total of eight articles. These were assessed for bias using the methodological index for nonrandomized studies (MINORS criteria) and reported using the synthesis without meta-analysis guideline (SWiM). Results: One hundred eighty patients underwent treatment for liver metastases from colorectal cancer. The median transverse diameter of tumours treated by IRE was <3 cm. Ninety-four (52%) tumours were adjacent to major hepatic inflow/outflow structures or the vena cava. IRE was undertaken under general anaesthesia with cardiac cycle synchronisation and with the use of either CT or ultrasound for lesion localisation. Probe spacing was less than 3.2 cm for all ablations. There were two (1.1%) procedure-related deaths in 180 patients. There was one (0.5%) post-operative haemorrhage requiring laparotomy, one (0.5%) bile leak, five (2.8%) post-procedure biliary strictures and a zero incidence of post-IRE liver failure. Conclusions: This systematic review shows that IRE for colorectal liver metastases can be accomplished with low procedure-related morbidity and mortality. Further prospective study is required to assess the role of IRE in the portfolio of treatments for patients with liver metastases from colorectal cancer. Full article
(This article belongs to the Special Issue Current Status of Irreversible Electroporation for Colorectal Hepatic Metastases)
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