Skull Base Reconstruction Following Surgical Treatment of Sinonasal and/or Intracranial Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 3166

Special Issue Editor


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Guest Editor
1. Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, CA 92868, USA
2. Department of Neurological Surgery, University of California Irvine, Orange, CA 92868, USA
Interests: sinonasal and skull base tumors; nasopharyngeal carcinoma; skull base reconstruction; rare tumors of the head and neck

Special Issue Information

Dear Colleagues,

As our understanding of tumor pathophysiology and principles surrounding technical access and oncologic resection have improved over time, many primary sinonasal or intracranial tumors bordering the skull base may now be safely and effectively treated via the endoscopic endonasal route. A critical component of such surgery is skull base reconstruction, where the intracranial space must be separated from the sinonasal cavity to restore physiological function and prevent morbidity and infection. Previously thought of as the major limitation of the endoscopic endonasal approach, advances in and an improved understanding of skull base reconstruction has now led to refined outcomes with acceptably low complication rates.

This Special Issue will cover various topics in skull base reconstruction related to tumor surgery, and aim to promote additional research in this active area of investigation. We welcome submissions on the following subtopics (but are not limited to these, as long as the research is within the scope of the Special Issue theme):

  • Reconstructive outcomes following treatment of sinonasal/skull base tumors;
  • New techniques for open, endoscopic, or combined skull base reconstruction;
  • Reconstruction options for the previously irradiated or surgerized nasal cavity;
  • Postoperative precautions to improve outcomes following skull base reconstruction;
  • Means to balance morbidity and quality of life and reconstructive outcomes.

We look forward to receiving your contributions.

Dr. Edward C. Kuan
Guest Editor

Manuscript Submission Information

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Keywords

  • reconstruction
  • cerebrospinal fluid leak
  • nasoseptal flap
  • pericranial flap
  • endoscopic skull base surgery
  • cranial base
  • skull base
  • quality of life

Published Papers (3 papers)

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Research

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10 pages, 1993 KiB  
Article
Virtual Surgical Planning and Three-Dimensional Models for Precision Sinonasal and Skull Base Surgery
by Conall W. Fitzgerald, Mohammad Hararah, Tim Mclean, Robbie Woods, Snjezana Dogan, Viviane Tabar, Ian Ganly, Evan Matros and Marc A. Cohen
Cancers 2023, 15(20), 4989; https://doi.org/10.3390/cancers15204989 - 14 Oct 2023
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Abstract
Sinonasal and skull base malignancies represent a rare, heterogenous group of pathologies with an incidence of 0.556 per 100,000 persons in the population. Given the numerous critical anatomic structures located adjacent to the sinonasal cavity and skull base, surgery for tumors in this [...] Read more.
Sinonasal and skull base malignancies represent a rare, heterogenous group of pathologies with an incidence of 0.556 per 100,000 persons in the population. Given the numerous critical anatomic structures located adjacent to the sinonasal cavity and skull base, surgery for tumors in this region requires careful pre-operative planning with the assistance of radiological imaging and intraoperative image guidance technologies to reduce the risk of complications. Virtual surgical planning (VSP) and three-dimensional models (3DMs) are adjunctive technologies which assist clinicians to better visualize patient anatomy using enhanced digital radiological images and physical stereolithographic models based on patients’ personal imaging. This review summarizes our institutional experience with VSP and 3DMs in sinonasal and skull base surgical oncology. A clinical case series is used to thematically illustrate the application of VSP and 3DMs in surgical ablation, reconstruction, patient communication, medical education, and interdisciplinary teamwork in sinonasal and skull base surgery. Full article
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12 pages, 1431 KiB  
Review
Skull Base Reconstruction by Subsite after Sinonasal Malignancy Resection
by Kristen Kraimer and Mathew Geltzeiler
Cancers 2024, 16(2), 242; https://doi.org/10.3390/cancers16020242 - 05 Jan 2024
Viewed by 672
Abstract
Reconstruction after the resection of sinonasal malignancies is complex and primarily dependent on the defect size and location. While the reconstructive paradigm for sellar mass resection is well delineated, the challenges associated with reconstruction after sinonasal malignancy resection are less well described. This [...] Read more.
Reconstruction after the resection of sinonasal malignancies is complex and primarily dependent on the defect size and location. While the reconstructive paradigm for sellar mass resection is well delineated, the challenges associated with reconstruction after sinonasal malignancy resection are less well described. This narrative review will address the goals of reconstruction after both endonasal endoscopic and open sinonasal malignancy resection and reconstructive options specific to these subsites. The goals of reconstruction include repairing cerebrospinal fluid leaks, restoring sinonasal function, providing a nasal airway, and optimizing the patient’s quality of life. These goals are often complicated by the anatomic nuances of each involved sinus. In this review, we will discuss the methods of reconstruction specific to each sinonasal subsite and describe the factors that guide choosing the optimal reconstructive technique. Full article
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14 pages, 2351 KiB  
Review
Reconstruction of the Anterior Skull Base Using the Nasoseptal Flap: A Review
by Michael T. Werner, Desmond Yeoh, Judd H. Fastenberg, Mark B. Chaskes, Aron Z. Pollack, John A. Boockvar, David J. Langer, Randy S. D’Amico, Jason A. Ellis, Brett A. Miles and Charles C. L. Tong
Cancers 2024, 16(1), 169; https://doi.org/10.3390/cancers16010169 - 29 Dec 2023
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Abstract
The nasoseptal flap is a workhorse reconstructive option for anterior skull base defects during endonasal surgery. This paper highlights the versatility of the nasoseptal flap. After providing a brief historical perspective, this review will focus on the relevant primary literature published in the [...] Read more.
The nasoseptal flap is a workhorse reconstructive option for anterior skull base defects during endonasal surgery. This paper highlights the versatility of the nasoseptal flap. After providing a brief historical perspective, this review will focus on the relevant primary literature published in the last ten years. We will touch upon new applications of the flap, how the flap has been modified to expand its reach and robustness, and some of the current limitations. We will conclude by discussing what the future holds for improving upon the design and use of the nasoseptal flap in anterior skull base reconstruction. Full article
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