Large Granular Lymphocytic Leukemia: Genomics and Immunome
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 22874
Special Issue Editor
Interests: bone marrow failure disorders; genomics; RNA splicing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Large granular lymphocytic leukemia is a heterogeneous clonal disease characterized by the chronic proliferation of cytotoxic lymphocytes. A distinct immunophenotype (CD8+ Tαβ, CD4+ Tαβ, Tγδ, NK) is often found in a subset of patients. The clinical course of the disease encompasses indolent, symptomatic, and aggressive conditions. Integrated genomic analyses have identified alterations in gene pathways (e.g., STAT3, STAT5b) possibly driving cytotoxic clonal proliferation. More importantly, the genetic status of STAT3 and STAT5b has also been correlated with disease severity and immunophenotypic features. Large granular lymphocytic leukemia clones have been found in patients with other bone marrow failure disorders (aplastic anemia, paroxysmal nocturnal hemoglobinuria, and myelodysplastic syndrome), and their presence is sometimes associated with worse survival outcomes. Indeed, STAT3 mutation has been found in some patients with aplastic anemia and MDS with concomitant large granular lymphocytic leukemia clones. The fascinating notion of interconnected pathways and similar pathogenesis explaining this association has been a topic of extensive research. This Special Issue on large granular lymphocytic leukemia will cover the latest discoveries on the genomic landscape of this disease and immunologic aspects of this disorder. Specific emphasis will be given to comprehensive literature reviews highlighting the coexistence of large granular lymphocytic leukemia with other bone marrow failure disorders and the immunologic overview of the disease.
Dr. Valeria Visconte
Guest Editor
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Keywords
- genetics
- immune phenotype
- T-cell clonality