Metabolic Adaptations in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 25 February 2025 | Viewed by 43
Special Issue Editor
Interests: respiration; angiogenesis; glycolysis; mitochondria; Sirt3
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Malignant tumors have unique metabolic demands, which are required for growth under low oxygen but can also serve as vulnerabilities. These include metabolic adaptations to respiration with low oxygen. As respiration is required for tumor growth, even with oxygen limitations, tumors have adapted to alternative forms of respiration. Known adaptations include using alternatives to glucose to generate ATP, including glutamine and fatty acid oxidation, and providing intermediates that can be used in cellular respiration. Other adaptations include metabolic plasticity between respiration and glycolysis. Interventions that limit the plasticity of metabolism may render solid tumors unable to grow under hypoxic conditions, and certain respiratory adaptations, such as Sox2 expression, may govern the ability of tumors to metastasize or differentiate. Metabolic characteristics of cancer stem cells will be explored, including use of alternative substrates to glucose and respiratory adaptations that distinguish cancer stem cells from normal stem cells and normal respiration will be of particular interest.
Prof. Dr. Jack L. Arbiser
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- Sox2
- Sirt3
- glycolysis
- respiration
- fatty acid oxidation
- NFkB
